1-(4-methylphenyl)-2,3-di(morpholin-4-yl)-3-phenylpropan-1-one

Base Information

• Chemical Name: 1-(4-methylphenyl)-2,3-di(morpholin-4-yl)-3-phenylpropan-1-one
• CAS No.: 32045-93-5
• Molecular Formula: C24H30 N2 O3
• Molecular Weight: 394.5066
• Mol file: 32045-93-5.mol

Synonyms:NSC 33582

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Chemical Property of 1-(4-methylphenyl)-2,3-di(morpholin-4-yl)-3-phenylpropan-1-one

Chemical Property:

• Vapor Pressure: 2.2E-12mmHg at 25°C
• Boiling Point: 555.6°C at 760 mmHg
• Flash Point: 289.8°C
• Density: 1.163g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-methylphenyl)-2,3-di(morpholin-4-yl)-3-phenylpropan-1-one

There total 3 articles about 1-(4-methylphenyl)-2,3-di(morpholin-4-yl)-3-phenylpropan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + 3-phenyl-1-p-tolylprop-2-en-1-one (4224-96-8) → 2,3-dimorpholino-3-phenyl-1-(p-tolyl)propan-1-one (32045-93-5)

Guidance literature:

With iodine; potassium carbonate; In tetrahydrofuran; at 50 ℃; for 3h;

DOI:10.1002/asia.201900170

Reference yield:

morpholine (110-91-8,99108-56-2) + (2RS,3SR)-2,3-dibromo-3-phenyl-1-p-tolyl-propan-1-one (10325-65-2,24213-11-4) → 2,3-dimorpholino-3-phenyl-1-(p-tolyl)propan-1-one (32045-93-5)

Guidance literature:

With ethanol;

DOI:10.1021/ja01200a005 DOI:10.1021/jo01158a007

Reference yield:

→ 2,3-dimorpholino-3-phenyl-1-(p-tolyl)propan-1-one (32045-93-5)

Guidance literature:

/BRN= 528901/ (IIa), Morpholin a)in Ethylalkohol b)in Benzol;

upstream raw materials:

morpholine

(2RS,3SR)-2,3-dibromo-3-phenyl-1-p-tolyl-propan-1-one

3-phenyl-1-p-tolylprop-2-en-1-one

Refernces

• 1、 Zhang, YongJian,Su, Junyi,Niu, Wenjie,Li, Yujin. "Iodine-promoted Intermolecular Dehydrogenation Diamination: Synthesis of Unsymmetrical α,β-Diamido Ketones". supporting information. p. 1477 - 1480. Retrieved 2019/03/26.