2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-

Base Information

• Chemical Name: 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-
• CAS No.: 88939-75-7
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• Mol file: 88939-75-7.mol

Synonyms:Methyl (E)-3-(2-aminophenyl)-2-propenoate;Methyl trans-o-aminocinnamate;2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-;

Chemical Property of 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-

Chemical Property:

• PSA: 52.32000
• LogP: 2.03620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)-

There total 32 articles about 2-Propenoic acid, 3-(2-aminophenyl)-, methyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-methyl 2-nitrocinnamate (39228-29-0) → methyl (2E)-3-(2-aminophenyl)propenoate (88939-75-7)

Guidance literature:

With borohydride exchange resin; nickel diacetate; In methanol; at 20 ℃; for 2.5h;

DOI:10.3987/COM-05-10425

Reference yield: 99.0%

2-iodophenylamine (615-43-0) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl (2E)-3-(2-aminophenyl)propenoate (88939-75-7)

Guidance literature:

With triethylamine; bis(N-methylimidazol-2-yl)Pd(Cl)Me; In various solvent(s); at 120 ℃; for 1h;

DOI:10.1021/ol030071d

Reference yield: 98.0%

methyl 2-nitrocinnamate (39228-29-0,105376-46-3,612-43-1) → methyl β-(o-aminophenyl)acrylate (88939-75-7,1664-62-6)

Guidance literature:

methyl 2-nitrocinnamate; With tin(II) chloride dihdyrate; In ethyl acetate; for 1h; Reflux;

With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃;

DOI:10.5012/bkcs.2010.31.11.3353

upstream raw materials:

methyl 2-nitrocinnamate

2-nitro-benzaldehyde

2-iodophenylamine

acrylic acid methyl ester

Downstream raw materials:

3-(2-(nitroacetylamino)phenyl)propenonic acid methyl ester

C₁₀H₉N₃O₂

C₂₁H₂₃NO₄S

C₂₁H₂₁NO₃S