1-Acetylaspidoalbidine

Base Information

Chemical Name:1-Acetylaspidoalbidine
CAS No.:56197-21-8
Molecular Formula:C21H26N2O2
Molecular Weight:338.4433
Hs Code.:
DSSTox Substance ID:DTXSID70331696
Nikkaji Number:J145.756J
Wikidata:Q27105315

Synonyms:1-acetylaspidoalbidine

Suppliers and Price of 1-Acetylaspidoalbidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 0 raw suppliers

Chemical Property of 1-Acetylaspidoalbidine

Chemical Property:

Vapor Pressure:9.6E-13mmHg at 25°C
Boiling Point:564°Cat760mmHg
Flash Point:294.9°C
Density:1.3g/cm³
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:338.199428076
Heavy Atom Count:25
Complexity:623

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1C2CCC34CCCN5C3(C2(CC5)C6=CC=CC=C61)OCC4
Isomeric SMILES:CC(=O)N1[C@@H]2CC[C@@]34CCCN5[C@]3([C@]2(CC5)C6=CC=CC=C61)OCC4

Technology Process of 1-Acetylaspidoalbidine

There total 44 articles about 1-Acetylaspidoalbidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 36459-35-5
(+)-fendleridine

: 108-24-7
acetic anhydride

: 2671-45-6,56197-21-8
1-Acetyl-aspidoalbidin

Guidance literature:: With pyridine; In dichloromethane; at 23 ℃; Inert atmosphere;
DOI:10.1021/acs.joc.9b00145

Reference yield:

: n-decyl 2-vinylbut-⁽²⁾-enoate

: 2671-45-6,56197-21-8
1-Acetyl-aspidoalbidin

Guidance literature:: Multi-step reaction with 14 steps

1.1: diisopropylamine; n-butyllithium; 1,3,4-trimethylimidazolidin-2-one / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 14 h / 23 °C / Inert atmosphere; Cooling with ice

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 6 h / 0 - 23 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; water / 40 h / 100 °C / Inert atmosphere; Sealed tube

4.1: N-ethyl-N,N-diisopropylamine; triphenylphosphine / dichloromethane / 16 h / -5 - 23 °C / Inert atmosphere

5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 18 h / 80 °C / Inert atmosphere; Sealed tube

6.1: palladium diacetate; p-benzoquinone; perchloric acid / acetonitrile; toluene / 6 h / 23 °C / Inert atmosphere

7.1: sodium tetrahydroborate / acetonitrile; toluene / 2 h / Inert atmosphere

8.1: triethylamine; Candida rugosa lipase / toluene / 6 h / 23 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction

9.1: platinum(IV) oxide; hydrogen / methanol; ethyl acetate / 16 h / 23 °C

10.1: dmap / dichloromethane / 12 h / Inert atmosphere

11.1: tri-n-butyl-tin hydride; trifluoromethylsulfonic anhydride / acetonitrile / 2.33 h / -40 - 23 °C / Inert atmosphere

12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 13 h / Inert atmosphere

13.1: trifluoroacetic acid; thiophenol / 5.5 h / 55 °C / Inert atmosphere

13.2: 12 h / Inert atmosphere

14.1: pyridine / dichloromethane / 6 h / 23 °C / Inert atmosphere

With pyridine; triethylsilane; dmap; 1,3,4-trimethylimidazolidin-2-one; platinum(IV) oxide; sodium tetrahydroborate; n-butyllithium; perchloric acid; Hoveyda-Grubbs catalyst second generation; trifluoromethylsulfonic anhydride; hydrogen; tri-n-butyl-tin hydride; palladium diacetate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; p-benzoquinone; sodium hydroxide; Candida rugosa lipase; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; toluene; acetonitrile; 6.1: |Wacker-Tsuji Olefin Oxidation;
DOI:10.1021/jacs.6b07623

Reference yield:

: C₁₈H₁₈INO

: 2671-45-6,56197-21-8
1-Acetyl-aspidoalbidin

Guidance literature:: Multi-step reaction with 14 steps

1.1: diisopropylamine; n-butyllithium; 1,3,4-trimethylimidazolidin-2-one / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 14 h / 23 °C / Inert atmosphere; Cooling with ice

2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 6 h / 0 - 23 °C / Inert atmosphere

3.1: sodium hydroxide / methanol; water / 40 h / 100 °C / Inert atmosphere; Sealed tube

4.1: N-ethyl-N,N-diisopropylamine; triphenylphosphine / dichloromethane / 16 h / -5 - 23 °C / Inert atmosphere

5.1: Hoveyda-Grubbs catalyst second generation / 1,2-dichloro-ethane / 18 h / 80 °C / Inert atmosphere; Sealed tube

6.1: palladium diacetate; p-benzoquinone; perchloric acid / acetonitrile; toluene / 6 h / 23 °C / Inert atmosphere

7.1: sodium tetrahydroborate / acetonitrile; toluene / 2 h / Inert atmosphere

8.1: triethylamine; Candida rugosa lipase / toluene / 6 h / 23 °C / Inert atmosphere; Resolution of racemate; Enzymatic reaction

9.1: platinum(IV) oxide; hydrogen / methanol; ethyl acetate / 16 h / 23 °C

10.1: dmap / dichloromethane / 12 h / Inert atmosphere

11.1: tri-n-butyl-tin hydride; trifluoromethylsulfonic anhydride / acetonitrile / 2.33 h / -40 - 23 °C / Inert atmosphere

12.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / methanol; acetonitrile / 13 h / Inert atmosphere

13.1: trifluoroacetic acid; thiophenol / 5.5 h / 55 °C / Inert atmosphere

13.2: 12 h / Inert atmosphere

14.1: pyridine / dichloromethane / 6 h / 23 °C / Inert atmosphere

With pyridine; triethylsilane; dmap; 1,3,4-trimethylimidazolidin-2-one; platinum(IV) oxide; sodium tetrahydroborate; n-butyllithium; perchloric acid; Hoveyda-Grubbs catalyst second generation; trifluoromethylsulfonic anhydride; hydrogen; tri-n-butyl-tin hydride; palladium diacetate; thiophenol; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; p-benzoquinone; sodium hydroxide; Candida rugosa lipase; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 1,2-dichloro-ethane; toluene; acetonitrile; 6.1: |Wacker-Tsuji Olefin Oxidation;
DOI:10.1021/jacs.6b07623