L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-iodoethyl ester

Base Information

• Chemical Name: L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-iodoethyl ester
• CAS No.: 88962-43-0
• Molecular Formula: C₂₂H₃₃IN₂O₅
• Molecular Weight: 532.419
• Mol file: 88962-43-0.mol

Synonyms:

Chemical Property of L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-iodoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-iodoethyl ester

There total 4 articles about L-Leucine, N-[N-[(phenylmethoxy)carbonyl]-L-isoleucyl]-, 2-iodoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-bromethylester (88962-32-7) → N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-iodethylester (88962-43-0)

Guidance literature:

With sodium iodide; In acetone; for 15h; Yield given; Ambient temperature;

Reference yield:

L-leucine (61-90-5,21675-61-6,25248-98-0,70-45-1) → N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-iodethylester (88962-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 80 percent / thionylchloride / 40 - 50 °C

2: 96 percent / triethylamine, chloroformic acid ethyl ester / CH₂Cl₂ / 1) -10 deg C, 1 h, 2) 2 h, room temperature

3: NaI / acetone / 15 h / Ambient temperature

With thionyl chloride; chloroformic acid ethyl ester; triethylamine; sodium iodide; In dichloromethane; acetone;

Reference yield:

N-Cbz-L-Isoleucine (3160-59-6) → N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-iodethylester (88962-43-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / triethylamine, chloroformic acid ethyl ester / CH₂Cl₂ / 1) -10 deg C, 1 h, 2) 2 h, room temperature

2: NaI / acetone / 15 h / Ambient temperature

With chloroformic acid ethyl ester; triethylamine; sodium iodide; In dichloromethane; acetone;

upstream raw materials:

N-Benzyloxycarbonyl-L-isoleucyl-L-leucin-2-bromethylester

L-leucine

N-Cbz-L-Isoleucine

Leucin-2-bromethylester-hydrochlorid

Downstream raw materials:

N-Benzyloxycarbonyl-L-isoleucyl-L-leucin

Refernces