Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate

Base Information

Chemical Name:Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate
CAS No.:88975-45-5
Molecular Formula:C₁₄H₁₇ClO₅
Molecular Weight:300.739
Hs Code.:
DSSTox Substance ID:DTXSID20558876
Wikidata:Q82441340

Synonyms:88975-45-5;Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate;DTXSID20558876

Suppliers and Price of Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:8
Exact Mass:300.0764513
Heavy Atom Count:20
Complexity:316

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(CC1=CC(=C(C=C1)O)Cl)C(=O)OCC

Technology Process of Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate

There total 1 articles about Diethyl [(3-chloro-4-hydroxyphenyl)methyl]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25814-36-2
diethyl (4-amino-3-chlorophenyl)methylmalonate

: 88975-45-5
diethyl (3-chloro-4-hydroxyphenyl)methylmalonate

Guidance literature:: With copper(I) oxide; sulfuric acid; water; copper(II) nitrate; sodium nitrite; Yield given. Multistep reaction; 1.) 0 deg C, 2 h; 2.) toluene, reflux, 15 min;
DOI:10.1248/cpb.31.3424

Reference yield:

: 88975-45-5
diethyl (3-chloro-4-hydroxyphenyl)methylmalonate

: 56355-36-3
2-(3-chloro-4-thiazol-2-yloxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / diethyl ether / 2 h / -10 °C

2: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

3: 80 percent / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

4: K₂CO₃ / methanol; H₂O / Heating

With hydrogen sulfide; potassium carbonate; toluene-4-sulfonic acid; triethylamine; In methanol; diethyl ether; water; acetic acid;
DOI:10.1248/cpb.31.3424

Reference yield:

: 88975-45-5
diethyl (3-chloro-4-hydroxyphenyl)methylmalonate

: 2-[3-Chloro-4-(thiazol-2-yloxy)-phenyl]-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / diethyl ether / 2 h / -10 °C

2: H₂S/triethylamine / diethyl ether / 0.83 h / Ambient temperature

3: 80 percent / p-toluenesulfonic acid / acetic acid / 1.5 h / 90 - 95 °C

With hydrogen sulfide; toluene-4-sulfonic acid; triethylamine; In diethyl ether; acetic acid;
DOI:10.1248/cpb.31.3424