(4-Methylphenyl)(1H-indole-3-yl) ketone

Base Information

• Chemical Name: (4-Methylphenyl)(1H-indole-3-yl) ketone
• CAS No.: 890-29-9
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• Hs Code.: 2933990090
• Mol file: 890-29-9.mol

Synonyms:3-p-Toluoyl-indole;Indol-3-yl-p-tolylketon;indol-3-yl-p-tolyl-methanone;

Chemical Property of (4-Methylphenyl)(1H-indole-3-yl) ketone

Chemical Property:

• Melting Point: 179-181 °C
• Boiling Point: 450.2±20.0 °C(Predicted)
• PKA: 15.28±0.30(Predicted)
• PSA: 32.86000
• Density: 1.198±0.06 g/cm3(Predicted)
• LogP: 3.70730

Purity/Quality:

95% ^*data from raw suppliers

(1H-INDOL-3-YL)-PARA-TOLYL-METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-Methylphenyl)(1H-indole-3-yl) ketone

There total 9 articles about (4-Methylphenyl)(1H-indole-3-yl) ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

indole (120-72-9) + p-toluoyl-1H-1,2,3-benzotriazole (59046-28-5) → (1H-indol-3-yl)(4-methylphenyl)methanone (890-29-9)

Guidance literature:

With titanium tetrachloride; In dichloromethane; at 25 ℃; for 2h;

DOI:10.1021/jo034187z

Reference yield: 86.0%

indole (120-72-9) + 4-methyl-benzoyl chloride (874-60-2) → (1H-indol-3-yl)(4-methylphenyl)methanone (890-29-9)

Guidance literature:

With aluminum oxide; In neat (no solvent); at 100 ℃; for 0.116667h; regioselective reaction; Microwave irradiation; Green chemistry;

DOI:10.1039/c3nj00854a

Reference yield: 75.0%

indole (120-72-9) + para-methylbenzonitrile (104-85-8) → (1H-indol-3-yl)(4-methylphenyl)methanone (890-29-9)

Guidance literature:

With [2,2]bipyridinyl; (1S)-10-camphorsulfonic acid; water; palladium diacetate; at 120 ℃; for 36h; Concentration; Reagent/catalyst; Solvent;

DOI:10.1021/ol303440y

upstream raw materials:

indole

p-toluoyl-1H-1,2,3-benzotriazole

p-Toluic acid

N-(4-methylbenzyl)aniline

Refernces

• 1、 Jaiswal, Anjali,Sharma, Anup Kumar,Singh, Krishna Nand. "Synthesis of 3-acylindoles: via copper-mediated oxidative decarbethoxylation of ethyl arylacetates". supporting information. p. 1623 - 1628. Retrieved 2020/03/06.
• 2、 Araki, Koji,Makino, Kosho,Tabata, Hidetsugu,Nakayama, Hiroshi,Zaitsu, Kei,Oshitari, Tetsuta,Natsugari, Hideaki,Takahashi, Hideyo. "Synthesis of 3-aroylindoles as intermediates of cannabimimetics and elucidation of their physicochemical properties". . p. 910 - 920. Retrieved 2018/06/07.