4-(2,6-Dichloroisonicotinoyl)morpholine

Base Information

Chemical Name:4-(2,6-Dichloroisonicotinoyl)morpholine
CAS No.:57803-44-8
Molecular Formula:C10H10Cl2N2O2
Molecular Weight:261.108
Hs Code.:9999999999
DSSTox Substance ID:DTXSID80973389
Nikkaji Number:J70.151C
Wikidata:Q82957285
Mol file:57803-44-8.mol

Synonyms:57803-44-8;4-(2,6-Dichloroisonicotinoyl)morpholine;(2,6-dichloropyridin-4-yl)(morpholino)methanone;(2,6-dichloropyridin-4-yl)-morpholin-4-ylmethanone;BRN 1119359;(2,6-dichloropyridin-4-yl)(morpholin-4-yl)methanone;Morpholine, 4-(2,6-dichloroisonicotinoyl)-;SCHEMBL798155;DTXSID80973389;MFCD01714001;AKOS008948691;CS-0191557;FT-0731874;E89596

Suppliers and Price of 4-(2,6-Dichloroisonicotinoyl)morpholine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AOBChem
(2,6-dichloropyridin-4-yl)(morpholino)methanone 97%
500mg
$ 247.00

Total 4 raw suppliers

Chemical Property of 4-(2,6-Dichloroisonicotinoyl)morpholine

Chemical Property:

Vapor Pressure:1.5E-08mmHg at 25°C
Boiling Point:457.4°Cat760mmHg
Flash Point:230.4°C
PSA：42.43000
Density:1.429g/cm³
LogP:1.79870
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:260.0119330
Heavy Atom Count:16
Complexity:249

Purity/Quality:

99% ^*data from raw suppliers

(2,6-dichloropyridin-4-yl)(morpholino)methanone 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1COCCN1C(=O)C2=CC(=NC(=C2)Cl)Cl

Technology Process of 4-(2,6-Dichloroisonicotinoyl)morpholine

There total 2 articles about 4-(2,6-Dichloroisonicotinoyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 110-91-8,99108-56-2
morpholine

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 530-62-1
1,1'-carbonyldiimidazole

: 57803-44-8
(2,6-dichloropyridin-4-yl)(morpholino)methanone

Guidance literature:: 2,6-dichloropyridine-4-carboxylic acid; 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 1h; Inert atmosphere;

morpholine; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 2h; Inert atmosphere;

Reference yield: 83.0%

: 110-91-8,99108-56-2
morpholine

: 42521-08-4
2,6-dichloroisonicotinoyl chloride

: 57803-44-8
(2,6-dichloropyridin-4-yl)(morpholino)methanone

Guidance literature:: With pyridine; In dichloromethane; for 2h; Cooling with ice;

Reference yield:

: 57803-44-8
(2,6-dichloropyridin-4-yl)(morpholino)methanone

: trans-4-{[6-[(6-amino-1,3-benzothiazol-2-yl)amino]-4-(4-morpholinylmethyl)-2-pyridinyl]amino}cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: diborane / dichloromethane; tetrahydrofuran / Inert atmosphere; Cooling with ice

1.2: Reflux

1.3: pH 7

2.1: ammonia / water; ethylene glycol / 24 h / 200 °C / Sealed tube; Microwave irradiation

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / Inert atmosphere; Cooling with ice

3.2: 20 °C

4.1: zinc; acetic acid / 0.5 h

5.1: ethylene glycol / 12 h / 220 °C / Sealed tube; Microwave irradiation

With ammonia; sodium hydride; acetic acid; diborane; zinc; In tetrahydrofuran; dichloromethane; water; ethylene glycol; mineral oil;