4-Hexen-1-ol, 6-[2,5-bis(methoxymethoxy)-3-methylphenyl]-4-methyl-, (4E)-

Base Information

Chemical Name:4-Hexen-1-ol, 6-[2,5-bis(methoxymethoxy)-3-methylphenyl]-4-methyl-, (4E)-
CAS No.:890527-19-2
Molecular Formula:C18H28O5
Molecular Weight:324.417
Hs Code.:

Synonyms:

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Chemical Property of 4-Hexen-1-ol, 6-[2,5-bis(methoxymethoxy)-3-methylphenyl]-4-methyl-, (4E)-

Chemical Property:

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Technology Process of 4-Hexen-1-ol, 6-[2,5-bis(methoxymethoxy)-3-methylphenyl]-4-methyl-, (4E)-

There total 9 articles about 4-Hexen-1-ol, 6-[2,5-bis(methoxymethoxy)-3-methylphenyl]-4-methyl-, (4E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 890527-13-6
2-[(2'E)-6'-tert-butyldimethylsilyloxy-3'-methyl-2'-hexen-1'-yl]-6-methyl-1,4-hydroquinone 1,4-dimethyl ether

: 890527-19-2
(E)-6-(2,5-Bis-methoxymethoxy-3-methyl-phenyl)-4-methyl-hex-4-en-1-ol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1248/cpb.54.391

Reference yield:

: 105-87-3,8022-83-1
3,7-dimethyl-2E,6-octadien-1-yl acetate

: 890527-19-2
(E)-6-(2,5-Bis-methoxymethoxy-3-methyl-phenyl)-4-methyl-hex-4-en-1-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 47 percent / K₂CO₃; K₃Fe(CN)6; K₂OsO₄ / 2-methyl-propan-2-ol; H₂O / 72 h / 4 °C

2.1: 98 percent / aq. NaIO₄ / acetone / 0 - 20 °C

3.1: 99 percent / NaBH₄ / methanol / 0 °C

4.1: 100 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 4 h / 20 °C

5.1: 100 percent / K₂CO₃ / methanol / 1 h / 0 °C

6.1: methanesulfonyl chloride; Et₃N / CHCl₃ / 0.5 h / 0 °C

7.1: lithium bromide / dimethylformamide / 1 h / 20 °C

8.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

8.2: CuI*PBu₃ / diethyl ether; hexane / 1.25 h / -60 °C

8.3: 75 percent / diethyl ether; hexane / 2.33 h / -60 - 0 °C

9.1: 68 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With dmap; sodium tetrahydroborate; potassium osmate(VI); sodium periodate; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium bromide; potassium hexacyanoferrate(III); In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;
DOI:10.1248/cpb.54.391

Reference yield:

: 35334-60-2
(E)-6-acetoxy-4-methyl-4-hexenal

: 890527-19-2
(E)-6-(2,5-Bis-methoxymethoxy-3-methyl-phenyl)-4-methyl-hex-4-en-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: 99 percent / NaBH₄ / methanol / 0 °C

2.1: 100 percent / Et₃N; 4-dimethylaminopyridine / CH₂Cl₂ / 4 h / 20 °C

3.1: 100 percent / K₂CO₃ / methanol / 1 h / 0 °C

4.1: methanesulfonyl chloride; Et₃N / CHCl₃ / 0.5 h / 0 °C

5.1: lithium bromide / dimethylformamide / 1 h / 20 °C

6.1: BuLi / diethyl ether; hexane / 1 h / -78 °C

6.2: CuI*PBu₃ / diethyl ether; hexane / 1.25 h / -60 °C

6.3: 75 percent / diethyl ether; hexane / 2.33 h / -60 - 0 °C

7.1: 68 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C

With dmap; sodium tetrahydroborate; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; methanesulfonyl chloride; triethylamine; lithium bromide; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.54.391