2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine

Base Information

• Chemical Name: 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine
• CAS No.: 89075-43-4
• Molecular Formula: C12H8FN3
• Molecular Weight: 213.214
• ChEMBL ID: CHEMBL349422
• DSSTox Substance ID: DTXSID10541191
• Wikidata: Q82417464
• Mol file: 89075-43-4.mol

Synonyms:89075-43-4;2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine;2-(2-FLUOROPHENYL)-1H-IMIDAZO[4,5-C]PYRIDINE;3H-Imidazo[4,5-c]pyridine, 2-(2-fluorophenyl)-;1H-Imidazo[4,5-c]pyridine, 2-(2-fluorophenyl)-;SCHEMBL541991;CHEMBL349422;SCHEMBL1436389;SCHEMBL10416988;DTXSID10541191;DFXVIZQVJLSYOJ-UHFFFAOYSA-N;CS-M1547;MFCD18305807;AKOS012572411;AKOS030619177;CS-13598;C11572

Chemical Property of 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine

Chemical Property:

• PSA: 41.57000
• LogP: 2.76400
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 213.07022543
• Heavy Atom Count: 16
• Complexity: 248

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(2-Fluorophenyl)-3H-imidazo[4,5-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C2=NC3=C(N2)C=NC=C3)F

Technology Process of 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine

There total 2 articles about 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3,4-diaminopyridine (54-96-6) + o-fluoro-benzoic acid (445-29-4) → 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine (89075-43-4)

Guidance literature:

With PPA; at 190 ℃; for 3h;

Reference yield: 76.0%

→ 2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine (89075-43-4)

Guidance literature:

With polyphosphoric acid; at 100 - 160 ℃; for 12h;

Reference yield: 53.0%

2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine (89075-43-4) + 1-bromomethyl-4-bromobenzene (589-15-1) → 5-[(4-bromophenyl)methyl]-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine

Guidance literature:

2-(2-fluorophenyl)-3H-imidazo[4,5-c]pyridine; With sodium hydroxide; In DMF (N,N-dimethyl-formamide); water; at 0 ℃; for 0.25h;

1-bromomethyl-4-bromobenzene; In DMF (N,N-dimethyl-formamide); water; at 20 ℃; for 24h;

upstream raw materials:

3,4-diaminopyridine

o-fluoro-benzoic acid

Downstream raw materials:

C₁₉H₁₃FN₄O₂

C₁₉H₂₀FN₃

C₂₀H₁₆FN₃O

5-((6-(2,4-bis(trifluoromethyl)phenyl)pyridazin-3-yl)methyl)-2-(2-fluorophenyl)-5H-imidazo[4,5-c]pyridine