2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, (2R,3R)-rel-

Base Information

Chemical Name:2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, (2R,3R)-rel-
CAS No.:112628-52-1
Molecular Formula:C₂₁H₂₆N₂O
Molecular Weight:322.45
Hs Code.:

Synonyms:2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, trans-(?à)-; 2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, trans-; Vesamicol 72

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Chemical Property of 2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, (2R,3R)-rel-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, (2R,3R)-rel-

There total 4 articles about 2-Naphthalenol,5-amino-1,2,3,4-tetrahydro-3-(4-phenyl-1-piperidinyl)-, (2R,3R)-rel- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32666-56-1
1-amino-5,8-dihydronaphthalene

: 112628-52-1,141436-23-9
(±)-5-amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: benzene / 1 h / 0 °C

2: 85 percent / 80-85percent 3-chloroperoxybenzoic acid / diethyl ether / 5 h / 23 °C

3: 35 percent / ethanol / a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; benzene;
DOI:10.1021/jm00126a013

Reference yield:

: 134-32-7
1-amino-naphthalene

: 112628-52-1,141436-23-9
(±)-5-amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / NH₃, Na / diethyl ether; 2-methyl-propan-2-ol

2: benzene / 1 h / 0 °C

3: 85 percent / 80-85percent 3-chloroperoxybenzoic acid / diethyl ether / 5 h / 23 °C

4: 35 percent / ethanol / a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h

With ammonia; sodium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol; tert-butyl alcohol; benzene;
DOI:10.1021/jm00126a013

Reference yield:

: 115348-07-7
N-(5,8-dihydronaphthalen-1-yl)-2,2,2-trifluoroacetamide

: 112628-52-1,141436-23-9
(±)-5-amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / 80-85percent 3-chloroperoxybenzoic acid / diethyl ether / 5 h / 23 °C

2: 35 percent / ethanol / a) 45 deg C, 17 h, b) reflux, 3 h, c) 23 deg C, 7 h

With 3-chloro-benzenecarboperoxoic acid; In diethyl ether; ethanol;
DOI:10.1021/jm00126a013