2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)-

Base Information

• Chemical Name: 2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)-
• CAS No.: 89143-32-8
• Molecular Formula: C16H20N2O2
• Molecular Weight: 272.34200
• DSSTox Substance ID: DTXSID80386612
• Mol file: 89143-32-8.mol

Synonyms:2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)-;89143-32-8;1-benzyl-3-(piperidin-1-yl)pyrrolidine-2,5-dione;CBMicro_032206;Cambridge id 5760064;MixCom6_001870;SCHEMBL22426230;DTXSID80386612;STL020050;AKOS000526058;AKOS016318487;WAY-601128;BIM-0032080.P001;1-benzyl-3-(1-piperidinyl)-2,5-pyrrolidinedione;Z44427198;1-benzyl-3-(piperidin-1-yl)-1h-pyrrolidine-2,5-dione

Chemical Property of 2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)-

Chemical Property:

• PSA: 40.62000
• LogP: 1.67580
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 272.152477885
• Heavy Atom Count: 20
• Complexity: 371

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C2CC(=O)N(C2=O)CC3=CC=CC=C3

Technology Process of 2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)-

There total 4 articles about 2,5-Pyrrolidinedione, 1-(phenylmethyl)-3-(1-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

piperidine (110-89-4) + 1-benzyl-1H-pyrrole-2,5-dione (1631-26-1) → 1-benzyl-3-(piperidin-1-yl)pyrrolidine-2,5-dione (89143-32-8)

Guidance literature:

With triethylamine; lithium chloride; In tetrahydrofuran; at 23 ℃; for 1.5h; chemoselective reaction;

DOI:10.1002/adsc.201800160

Reference yield:

N-benzylmaleamic acid (15329-69-8) → 1-benzyl-3-(piperidin-1-yl)pyrrolidine-2,5-dione (89143-32-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / Heating

2: benzene

With acetic acid; In benzene; 1: Dehydration / 2: Addition;

Reference yield:

benzylamine (100-46-9) → 1-benzyl-3-(piperidin-1-yl)pyrrolidine-2,5-dione (89143-32-8)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: acetic acid / Heating

3: benzene

With acetic acid; In diethyl ether; benzene; 1: Addition / 2: Dehydration / 3: Addition;

upstream raw materials:

piperidine

1-benzyl-1H-pyrrole-2,5-dione

N-benzylmaleamic acid

benzylamine