5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-

Base Information

Chemical Name:5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-
CAS No.:84142-01-8
Molecular Formula:C₁₇H₁₇ClN₂
Molecular Weight:284.788
Hs Code.:
DSSTox Substance ID:DTXSID10233029
Nikkaji Number:J74.732G
Mol file:84142-01-8.mol

Synonyms:84142-01-8;BRN 5754946;5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-;10-(2-Aminoethyl)-8-chloro-5-methyl-5H-dibenz(b,f)azepine;Chloro-8 methyl-5 5H-dibenz(b,f)azepine-10-ethanamine [French];Chloro-8 methyl-5 5H-dibenz(b,f)azepine-10-ethanamine;10-(2-Aminoethyl)-8-chloro-5-methyl-5H-dibenz[b,f]azepine;DTXSID10233029;LS-60355

Suppliers and Price of 5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
10-(2-AMINOETHYL)-8-CHLORO-5-METHYL-5H-DIBENZ(B,F)AZEPINE 95.00%
5MG
$ 496.71

Total 3 raw suppliers

Chemical Property of 5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-

Chemical Property:

Vapor Pressure:2E-08mmHg at 25°C
Boiling Point:453.8°C at 760 mmHg
Flash Point:228.3°C
PSA：29.26000
Density:1.189g/cm³
LogP:5.07600
XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:284.1080262
Heavy Atom Count:20
Complexity:368

Purity/Quality:: 10-(2-AMINOETHYL)-8-CHLORO-5-METHYL-5H-DIBENZ(B,F)AZEPINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=C(C=C2)Cl)C(=CC3=CC=CC=C31)CCN

Technology Process of 5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl-

There total 9 articles about 5H-Dibenz(b,f)azepine, 10-(2-aminoethyl)-8-chloro-5-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 11-(2-Azido-ethyl)-2-chloro-5-methyl-5H-dibenzo[b,f]azepine

: 84142-01-8
chloro-8 methyl-5 5H-dibenzylazepine-10-ethanamine

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; 1.) 0 deg C, 1h, 2.) room temp., 1h;

Reference yield:

: 31379-91-6
chloro-8 dihydro-5,11 methyl-5 10H-dibenzazepine-10-one

: 84142-01-8
chloro-8 methyl-5 5H-dibenzylazepine-10-ethanamine

Guidance literature:: Multi-step reaction with 8 steps

1: Zn / tetrahydrofuran / 4 h / 10 °C

2: 10.3 g / 2N HCl / methanol / 4 h

3: 86 percent / KOH / ethanol / 2 h

4: 81 percent / CH₂Cl₂ / 0.25 h / 0 °C

5: 87 percent / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., 30 min

6: 96 percent / pyridine / 5 h / Ambient temperature

7: sodium azide / ethanol / 12 h / Heating

8: 3.7 g / LiAlH₄ / diethyl ether / 1.) 0 deg C, 1h, 2.) room temp., 1h

With pyridine; hydrogenchloride; potassium hydroxide; lithium aluminium tetrahydride; sodium azide; zinc; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;

Reference yield:

: 4904-83-0
5-methyl-10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine

: 84142-01-8
chloro-8 methyl-5 5H-dibenzylazepine-10-ethanamine

Guidance literature:: Multi-step reaction with 9 steps

1: 66 percent / N-chlorosuccinimide / dimethylformamide / 1.)10 min, room temp., 2.) 45 min, 50 deg C

2: Zn / tetrahydrofuran / 4 h / 10 °C

3: 10.3 g / 2N HCl / methanol / 4 h

4: 86 percent / KOH / ethanol / 2 h

5: 81 percent / CH₂Cl₂ / 0.25 h / 0 °C

6: 87 percent / LiAlH₄ / tetrahydrofuran / 1.) 0 deg C, 30 min, 2.) room temp., 30 min

7: 96 percent / pyridine / 5 h / Ambient temperature

8: sodium azide / ethanol / 12 h / Heating

9: 3.7 g / LiAlH₄ / diethyl ether / 1.) 0 deg C, 1h, 2.) room temp., 1h

With pyridine; hydrogenchloride; potassium hydroxide; N-chloro-succinimide; lithium aluminium tetrahydride; sodium azide; zinc; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;