3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid

Base Information

Chemical Name:3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid
CAS No.:89224-62-4
Molecular Formula:C18H13NO4
Molecular Weight:307.306
Hs Code.:
ChEMBL ID:CHEMBL44456
DSSTox Substance ID:DTXSID10529333
Wikidata:Q82399700

Synonyms:3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid;89224-62-4;CHEMBL44456;SCHEMBL10653794;DTXSID10529333;UIUZYXSRFZINPJ-UHFFFAOYSA-N

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:307.08445790
Heavy Atom Count:23
Complexity:450

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(OC2=C1N(C3=CC=CC=C32)C4=CC=CC=C4)C(=O)O

Technology Process of 3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid

There total 6 articles about 3-Methoxy-4-phenyl-4H-furo[3,2-b]indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 89224-60-2
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxylic acid methyl ester

: 89224-62-4
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; for 17h; Heating;

Reference yield:

: 71711-33-6
3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester

: 89224-62-4
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / potassium carbonate / acetone / 24 h / Heating

2: 60 percent / potassium t-butoxide / tetrahydrofuran / 18 h

3: 81 percent / potassium carbonate / acetone / 48 h / Heating

4: 45 percent / 1N NaOH / methanol; H₂O / 17 h / Heating

With sodium hydroxide; potassium tert-butylate; potassium carbonate; In tetrahydrofuran; methanol; water; acetone;

Reference yield:

: 85793-68-6
2-<(carboxymethyl)phenylamino>benzoic acid

: 89224-62-4
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: conc. H₂SO₄ / 20 h / Heating

2: 71 percent / sodium methoxide / methanol / 1.5 h / Heating

3: 67 percent / potassium carbonate / acetone / 24 h / Heating

4: 60 percent / potassium t-butoxide / tetrahydrofuran / 18 h

5: 81 percent / potassium carbonate / acetone / 48 h / Heating

6: 45 percent / 1N NaOH / methanol; H₂O / 17 h / Heating

With sodium hydroxide; sulfuric acid; potassium tert-butylate; sodium methylate; potassium carbonate; In tetrahydrofuran; methanol; water; acetone;