3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide

Base Information

Chemical Name:3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide
CAS No.:89224-80-6
Molecular Formula:C18H14N2O3
Molecular Weight:306.321
Hs Code.:
DSSTox Substance ID:DTXSID90529336
Wikidata:Q82399705

Synonyms:89224-80-6;3-METHOXY-4-PHENYL-4H-FURO[3,2-B]INDOLE-2-CARBOXAMIDE;SCHEMBL10654374;DTXSID90529336

Suppliers and Price of 3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:306.10044231
Heavy Atom Count:23
Complexity:452

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(OC2=C1N(C3=CC=CC=C32)C4=CC=CC=C4)C(=O)N

Technology Process of 3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide

There total 6 articles about 3-Methoxy-4-phenyl-4H-furo[3,2-B]indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 89224-60-2
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxylic acid methyl ester

: 89224-80-6
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxamide

Guidance literature:: With ammonia; lithium; ferric nitrate; In tetrahydrofuran; for 16h;

Reference yield:

: 71711-33-6
3-hydroxy-1-phenyl-1H-indole-2-carboxylic acid methyl ester

: 89224-80-6
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 67 percent / potassium carbonate / acetone / 24 h / Heating

2: 60 percent / potassium t-butoxide / tetrahydrofuran / 18 h

3: 81 percent / potassium carbonate / acetone / 48 h / Heating

4: 61 percent / anhydrous ammonia, lithium / hydrated ferric nitrate / tetrahydrofuran / 16 h

With potassium tert-butylate; ammonia; lithium; potassium carbonate; ferric nitrate; In tetrahydrofuran; acetone;

Reference yield:

: 85793-68-6
2-<(carboxymethyl)phenylamino>benzoic acid

: 89224-80-6
3-methoxy-4-phenyl-4H-furo<3,2-b>indole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: conc. H₂SO₄ / 20 h / Heating

2: 71 percent / sodium methoxide / methanol / 1.5 h / Heating

3: 67 percent / potassium carbonate / acetone / 24 h / Heating

4: 60 percent / potassium t-butoxide / tetrahydrofuran / 18 h

5: 81 percent / potassium carbonate / acetone / 48 h / Heating

6: 61 percent / anhydrous ammonia, lithium / hydrated ferric nitrate / tetrahydrofuran / 16 h

With sulfuric acid; potassium tert-butylate; ammonia; sodium methylate; lithium; potassium carbonate; ferric nitrate; In tetrahydrofuran; methanol; acetone;