O-(3-Methoxyphenyl)hydroxylamine

Base Information

• Chemical Name: O-(3-Methoxyphenyl)hydroxylamine
• CAS No.: 89232-58-6
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• DSSTox Substance ID: DTXSID50531839
• Wikidata: Q82403992
• Mol file: 89232-58-6.mol

Synonyms:O-(3-Methoxyphenyl)hydroxylamine;89232-58-6;Hydroxylamine, O-(3-methoxyphenyl)-;SCHEMBL8176235;DTXSID50531839;MFCD30184313;SY282041;CS-0458630

Chemical Property of O-(3-Methoxyphenyl)hydroxylamine

Chemical Property:

• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 139.063328530
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC=C1)ON

Technology Process of O-(3-Methoxyphenyl)hydroxylamine

There total 4 articles about O-(3-Methoxyphenyl)hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-(3-methoxy)-phenoxyphtalimide → O-(3-methoxyphenyl)hydroxylamine (89232-58-6)

Guidance literature:

With hydrazine hydrate; In methanol; chloroform; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200601001

Reference yield:

O-methylresorcine (150-19-6) → O-(3-methoxyphenyl)hydroxylamine (89232-58-6)

Guidance literature:

With sodium hydride; O-(2,4-dinitrophenyl)hydroxylamine; Yield given. Multistep reaction; 1) DMF, 0-20 deg C, 30 min, 2.) 20 deg C, 2h;

DOI:10.1021/jo00182a007

Reference yield:

3-methoxyphenylboronic acid (10365-98-7,1107579-37-2) → O-(3-methoxyphenyl)hydroxylamine (89232-58-6)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride; pyridine / 1,2-dichloro-ethane / 20 °C / Molecular sieve

2: hydrazine hydrate / methanol; chloroform / 20 °C / Inert atmosphere

With pyridine; hydrazine hydrate; copper(l) chloride; In methanol; chloroform; 1,2-dichloro-ethane;

DOI:10.1039/c4cc05485g

upstream raw materials:

O-methylresorcine

C₂₆H₁₅F₁₇N₂O₅

3-methoxyphenylboronic acid

Downstream raw materials:

methoxyhydroquinone

(E)-1-phenylethanone O-(3-methoxyphenyl)oxime

1-(2-hydroxy-4-methoxyphenyl)-3-methylbutan-1-one

Benzophenone-3