methyl (5S,8R,9S,10S,13R,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-17-carboxyl ate

Base Information

• Chemical Name: methyl (5S,8R,9S,10S,13R,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-17-carboxyl ate
• CAS No.: 4139-88-2
• Molecular Formula: C21H32 O3
• Molecular Weight: 332.483
• Mol file: 4139-88-2.mol

Synonyms:5a-Androstane-17b-carboxylic acid, 3-oxo-, methylester (6CI,7CI,8CI); Etioallocholanic acid, 3-keto-, Me ester (4CI); L 629.917;NSC 12870

Chemical Property of methyl (5S,8R,9S,10S,13R,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-17-carboxyl ate

Chemical Property:

• Vapor Pressure: 2.04E-07mmHg at 25°C
• Boiling Point: 424.6°Cat760mmHg
• Flash Point: 182.8°C
• PSA: 43.37000
• Density: 1.078g/cm³
• LogP: 4.38740

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl (5S,8R,9S,10S,13R,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-17-carboxyl ate

There total 1 articles about methyl (5S,8R,9S,10S,13R,14S,17S)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9 ,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-17-carboxyl ate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

androst-4-en-3-one-17β-carboxylic acid (302-97-6) → methyl 3-oxo-5α-androstane-17β-carboxylate (4139-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: diethyl ether

2: palladium; methanol / anschliessend Hydrierung an Platin in Methanol und Essigsaeure

3: chromium (VI)-oxide; acetic acid

With chromium(VI) oxide; methanol; diethyl ether; palladium; acetic acid;

DOI:10.1002/hlca.193702001150

Reference yield:

methyl 3-oxo-5α-androstane-17β-carboxylate (4139-88-2) → methyl-5α-etianate (15173-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate; ethanolic sodium ethylate / 170 °C

2: diethyl ether

With diethyl ether; sodium ethanolate; hydrazine hydrate;

DOI:10.1002/hlca.194402701234

Reference yield:

methyl 3-oxo-5α-androstane-17β-carboxylate (4139-88-2) → 5α-etianic acid (6247-77-4) + 5α-androstane-carboxylic acid-(17α) (438-08-4,6247-77-4,6247-78-5,6711-24-6,15173-93-0)

Guidance literature:

With sodium ethanolate; hydrazine hydrate; at 170 ℃;

DOI:10.1002/hlca.194402701234

upstream raw materials:

androst-4-en-3-one-17β-carboxylic acid

Downstream raw materials:

5α-etianic acid

5α-androstane-carboxylic acid-(17α)

methyl-5α-etianate