Technology Process of Silane, [[2-(2-bromoethyl)-4-methoxyphenyl]ethynyl]trimethyl-
There total 5 articles about Silane, [[2-(2-bromoethyl)-4-methoxyphenyl]ethynyl]trimethyl- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,3,5-trimethyl-pyridine; dibromotriphenylphosphorane;
In
dichloromethane;
for 5h;
Ambient temperature;
DOI:10.1021/jo00183a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) AlCl3 2.)PCl5 / 1.) CS2, 0 deg C, 2.) phosphorus oxychloride, 40 to 45 deg C, 2.5 h
2: 93 percent / KOH / methanol; H2O / 0.17 h
3: 91 percent / lithium diisopropylamide / tetrahydrofuran / 1 h / Ambient temperature
4: 1.) n-butyllithium / 1.)THF, hexane, -78 degC 2.) room temperature, overnight
5: 80 percent / triphenylphosphine dibromide, collidine / CH2Cl2 / 5 h / Ambient temperature
With
2,3,5-trimethyl-pyridine; potassium hydroxide; n-butyllithium; aluminium trichloride; phosphorus pentachloride; lithium diisopropyl amide; dibromotriphenylphosphorane;
In
tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo00183a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / lithium diisopropylamide / tetrahydrofuran / 1 h / Ambient temperature
2: 1.) n-butyllithium / 1.)THF, hexane, -78 degC 2.) room temperature, overnight
3: 80 percent / triphenylphosphine dibromide, collidine / CH2Cl2 / 5 h / Ambient temperature
With
2,3,5-trimethyl-pyridine; n-butyllithium; lithium diisopropyl amide; dibromotriphenylphosphorane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00183a018
