6-Bromo-2-chloro-4,8-dimethylquinoline

Base Information

Chemical Name:6-Bromo-2-chloro-4,8-dimethylquinoline
CAS No.:89446-46-8
Molecular Formula:C11H9BrClN
Molecular Weight:270.55300
Hs Code.:
DSSTox Substance ID:DTXSID00561767

Synonyms:6-Bromo-2-chloro-4,8-dimethylquinoline;89446-46-8;SCHEMBL1129623;DTXSID00561767;TUIZVCPHHDYUBB-UHFFFAOYSA-N;MFCD21647769;6-bromo-2-chloro-4,8-dimethyl-quinoline

Suppliers and Price of 6-Bromo-2-chloro-4,8-dimethylquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 6-Bromo-2-chloro-4,8-dimethylquinoline

Chemical Property:

PSA：12.89000
LogP:4.26750
XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:268.96069
Heavy Atom Count:14
Complexity:212

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CC2=C1N=C(C=C2C)Cl)Br

Technology Process of 6-Bromo-2-chloro-4,8-dimethylquinoline

There total 1 articles about 6-Bromo-2-chloro-4,8-dimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89446-45-7
6-bromo-4,8-dimethyl-2-quinolone

: 99455-14-8
6-Bromo-2-chloro-8-methylquinoline

: 89446-46-8
6-bromo-2-chloro-4,8-dimethyl-quinoline

Guidance literature:: With trichlorophosphate;

Reference yield:

: 89446-46-8
6-bromo-2-chloro-4,8-dimethyl-quinoline

: 121269-21-4
(Z)-2-(2-Methoxy-4,8-dimethyl-quinolin-6-ylmethyl)-3-phenylamino-acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 94.9 percent / methanol / Heating

2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 5 min, 2) to -20 deg C

3: NaOMe / dimethylsulfoxide / 2 h / 90 - 95 °C

With n-butyllithium; sodium methylate; In methanol; dimethyl sulfoxide;
DOI:10.1021/jm00128a041

Reference yield:

: 89446-46-8
6-bromo-2-chloro-4,8-dimethyl-quinoline

: 121269-22-5
(Z)-2-(2-Dimethylamino-4,8-dimethyl-quinolin-6-ylmethyl)-3-phenylamino-acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / ethanol / Heating

2: 1) n-BuLi / 1) THF, hexane, -78 deg C, 5 min, 2) to -20 deg C

3: NaOMe / dimethylsulfoxide / 2 h / 90 - 95 °C

With n-butyllithium; sodium methylate; In ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00128a041