Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-

Base Information

Chemical Name:Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-
CAS No.:89451-88-7
Molecular Formula:C12H13ClO
Molecular Weight:208.688
Hs Code.:
DSSTox Substance ID:DTXSID80472685
Nikkaji Number:J1.566.371E

Synonyms:89451-88-7;Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-;2,2-Dimethyl-3-(4-chlorophenyl)cyclobutanone;SCHEMBL10750020;DTXSID80472685;JYEZBOSVTHMTQK-UHFFFAOYSA-N;AKOS019994116

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-

Chemical Property:

XLogP3:3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:208.0654927
Heavy Atom Count:14
Complexity:239

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(C(CC1=O)C2=CC=C(C=C2)Cl)C

Technology Process of Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl-

There total 2 articles about Cyclobutanone, 3-(4-chlorophenyl)-2,2-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 21678-37-5
N,N,2-trimethylpropionamide

: 89451-88-7
3-(4-chlorophenyl)-2,2-dimethylcyclobutanone

Guidance literature:: N,N,2-trimethylpropionamide; With trifluoromethylsulfonic anhydride; In dichloromethane; at -15 ℃; for 0.166667h;

4-vinylbenzyl chloride; With 2,3,5-trimethyl-pyridine; for 4h; Heating;
DOI:10.1016/S0040-4039(01)01224-2

Reference yield:

: 89441-41-8
1-(4-chlorophenyl)-1-bromo-2,2-dimethyl-3-butanone

: 89451-88-7
3-(4-chlorophenyl)-2,2-dimethylcyclobutanone

Guidance literature:: With sodium; In ethanol;

Reference yield: 76.0%

: 89451-88-7
3-(4-chlorophenyl)-2,2-dimethylcyclobutanone

: 89441-45-2,89441-46-3,89451-90-1
(+/-)-3t-(4-chloro-phenyl)-2,2-dimethyl-cyclopropane-r-carboxylic acid

Guidance literature:: 3-(4-chlorophenyl)-2,2-dimethylcyclobutanone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

With N-Bromosuccinimide; at -78 - 0 ℃; for 0.333333h;

With sodium hydroxide;
DOI:10.1016/S0040-4039(01)01224-2