4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide

Base Information

• Chemical Name: 4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide
• CAS No.: 89499-35-4
• Molecular Formula: BrH*C₅H₄BrNO₂S
• Molecular Weight: 302.974
• DSSTox Substance ID: DTXSID30527619
• Mol file: 89499-35-4.mol

Synonyms:4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide;89499-35-4;4-amino-5-bromothiophene-2-carboxylic acid;hydrobromide;4-Amino-5-bromothiophene-2-carboxylic acidhydrobromide;DTXSID30527619;A861159;SR-01000406253;SR-01000406253-1;4-Amino-5-bromothiophene-2-carboxylicacidhydrobromide;4-Amino-5-bromothiophene-2-carboxylic acid--hydrogen bromide (1/1)

Chemical Property of 4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide

Chemical Property:

• PSA: 91.56000
• LogP: 3.33030
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 302.83873
• Heavy Atom Count: 11
• Complexity: 155

Purity/Quality:

95+% ^*data from raw suppliers

4-Amino-5-bromothiophene-2-carboxylic acidhydrobromide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=C(SC(=C1N)Br)C(=O)O.Br

Technology Process of 4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide

There total 4 articles about 4-Amino-5-bromothiophene-2-carboxylic acid hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-acetylamino-5-bromo-thiophene-2-carboxylic acid methyl ester (89499-31-0) → 4-Amino-5-bromo-thiophene-2-carboxylic acid; hydrobromide (89499-35-4)

Guidance literature:

With hydrogen bromide; Heating;

DOI:10.1007/BF00842830

Reference yield: 70.0%

4-Acetylamino-5-bromo-thiophene-2-carboxylic acid (89499-30-9) → 4-Amino-5-bromo-thiophene-2-carboxylic acid; hydrobromide (89499-35-4)

Guidance literature:

With hydrogen bromide; Heating;

DOI:10.1007/BF00842830

Reference yield:

5-bromo-4-nitro-thiophene-2-carboxylic acid (89283-24-9) → 4-Amino-5-bromo-thiophene-2-carboxylic acid; hydrobromide (89499-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 74 percent / Fe / acetic acid / 75 - 80 °C

2: 70 percent / conc.HBr / Heating

With hydrogen bromide; iron; In acetic acid;

DOI:10.1007/BF00842830

upstream raw materials:

4-acetylamino-5-bromo-thiophene-2-carboxylic acid methyl ester

4-Acetylamino-5-bromo-thiophene-2-carboxylic acid

5-bromo-4-nitro-thiophene-2-carboxylic acid

methyl 5-bromo-4-nitrothiophene-2-carboxylate

Refernces