2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine

Base Information

Chemical Name:2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine
CAS No.:89543-62-4
Molecular Formula:C17H20N2
Molecular Weight:252.359
Hs Code.:
ChEMBL ID:CHEMBL18308
DSSTox Substance ID:DTXSID20604382

Synonyms:89543-62-4;CHEMBL18308;SCHEMBL11013456;DTXSID20604382;2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine;2-Methyl-4-(p-tolyl)-1,2,3,4-tetrahydroisoquinolin-8-amine

Suppliers and Price of 2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:252.162648646
Heavy Atom Count:19
Complexity:296

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2CN(CC3=C2C=CC=C3N)C

Technology Process of 2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine

There total 5 articles about 2-Methyl-4-(4-methylphenyl)-1,2,3,4-tetrahydroisoquinolin-8-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 102436-63-5
N-(2-aminobenzyl)-2-(methylamino)-1-(4'-tolyl)-1-ethanol

: 89543-62-4
8-amino-2-methyl-4-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sulfuric acid; In dichloromethane; at 6 - 8 ℃; for 0.5h;
DOI:10.1021/jm00157a012

Reference yield:

: 56222-08-3
(2-nitrobenzyl)methylamine

: 89543-62-4
8-amino-2-methyl-4-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / triethylamine / diethyl ether / 4 h / 18 - 25 °C

2: 89.7 percent / NaBH₄ / methanol; H₂O / 4 h / Ambient temperature

3: 73 percent / H₂ / Raney nickel / ethanol / 12 h / 760 Torr

4: 21 percent / conc. H₂SO₄ / CH₂Cl₂ / 0.5 h / 6 - 8 °C

With sodium tetrahydroborate; sulfuric acid; hydrogen; triethylamine; nickel; In methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jm00157a012

Reference yield:

: 619-41-0
4-(bromoacetyl)toluene

: 89543-62-4
8-amino-2-methyl-4-p-tolyl-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / triethylamine / diethyl ether / 4 h / 18 - 25 °C

2: 89.7 percent / NaBH₄ / methanol; H₂O / 4 h / Ambient temperature

3: 73 percent / H₂ / Raney nickel / ethanol / 12 h / 760 Torr

4: 21 percent / conc. H₂SO₄ / CH₂Cl₂ / 0.5 h / 6 - 8 °C

With sodium tetrahydroborate; sulfuric acid; hydrogen; triethylamine; nickel; In methanol; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jm00157a012