4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile

Base Information

Chemical Name:4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile
CAS No.:89549-69-9
Molecular Formula:C18H14N4O
Molecular Weight:302.335
Hs Code.:
DSSTox Substance ID:DTXSID80530037
Wikidata:Q82400883

Synonyms:89549-69-9;4-(4-METHOXYPHENYL)-6-(PHENYLAMINO)PYRIMIDINE-5-CARBONITRILE;4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile;DTXSID80530037

Suppliers and Price of 4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:302.11676108
Heavy Atom Count:23
Complexity:407

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=C(C(=NC=N2)NC3=CC=CC=C3)C#N

Technology Process of 4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile

There total 3 articles about 4-Anilino-6-(4-methoxyphenyl)pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 87412-76-8
1-phenyl-4-(p-anisyl)pyrazolo<3,4-d>pyrimidine

: 89549-69-9
6-anilino-4-(p-methoxyphenyl)-5-pyrimidinecarbonitrile

Guidance literature:: With sodium hydroxide; In dimethyl sulfoxide; for 3h; Ambient temperature;

Reference yield:

: 89549-59-7
4-(p-methoxyphenyl)-4,5-dihydro-1-phenyl-1H-pyrazolo<3,4-d>pyrimidine-4-carboxylic acid

: 89549-69-9
6-anilino-4-(p-methoxyphenyl)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / K₃Fe(CN)6, 50percent NaOH / H₂O; benzene / 1 h / Ambient temperature

2: 81 percent / 50percent NaOH / dimethylsulfoxide / 3 h / Ambient temperature

With sodium hydroxide; potassium hexacyanoferrate(III); In water; dimethyl sulfoxide; benzene;

Reference yield:

: 59563-87-0
(4-methoxy-phenyl)-(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-methanone

: 89549-69-9
6-anilino-4-(p-methoxyphenyl)-5-pyrimidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 59 percent / 50percent NaOH / dimethylsulfoxide / 1 h / Ambient temperature

2: 81 percent / K₃Fe(CN)6, 50percent NaOH / H₂O; benzene / 1 h / Ambient temperature

3: 81 percent / 50percent NaOH / dimethylsulfoxide / 3 h / Ambient temperature

With sodium hydroxide; potassium hexacyanoferrate(III); In water; dimethyl sulfoxide; benzene;