(S)-2-BENZYLOXY-METHYLPYRROLIDINE,

Base Information

• Chemical Name: (S)-2-BENZYLOXY-METHYLPYRROLIDINE,
• CAS No.: 89597-97-7
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Mol file: 89597-97-7.mol

Synonyms:

Chemical Property of (S)-2-BENZYLOXY-METHYLPYRROLIDINE,

Chemical Property:

• Boiling Point: 282℃
• Flash Point: 114℃
• Density: 1.009

Purity/Quality:

98.5% ^*data from raw suppliers

(2S)-2-(phenylmethoxymethyl)pyrrolidine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-BENZYLOXY-METHYLPYRROLIDINE,

There total 25 articles about (S)-2-BENZYLOXY-METHYLPYRROLIDINE, which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl (S)-2-((benzyloxy)methyl)pyrrolidine-1-carboxylate (130603-36-0) → (2S)-benzyloxymethyl-pyrrolidine (89597-97-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1.5h;

DOI:10.1039/c6ob02658c

Reference yield: 85.0%

N-Pent-4-enoyl-(S)-2-<(benzyloxy)methyl>pyrrolidine (172946-56-4) → (2S)-benzyloxymethyl-pyrrolidine (89597-97-7)

Guidance literature:

With water; iodine; In tetrahydrofuran; for 0.5h;

DOI:10.1021/jo00129a036

Reference yield: 66.0%

(6R)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-<(3,4-dimethoxybenzoyl)methyl>-2-piperidinone (164328-20-5) → (2S)-benzyloxymethyl-pyrrolidine (89597-97-7) + (2R)-2-<(2RS)-2-(3,4-Dimethoxyphenyl)-2-hydroxyethyl>piperidine

Guidance literature:

With boron trifluoride-tetrahydrofuran complex; In tetrahydrofuran; 1.) room temp., 15 min, 2.) reflux, 24 h;

DOI:10.1021/jo00124a025

upstream raw materials:

(S)-2-<(benzyloxy)methyl>-1-formylpyrrolidine

(6R)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-<(2-bromo-3,4-dimethoxybenzoyl)methyl>-2-piperidinone

(6R)-N-<(2S)-2-<(Benzyloxy)methyl>pyrrolidino>-6-<(3,4-dimethoxybenzoyl)methyl>-2-piperidinone

N-Pent-4-enoyl-(S)-2-<(benzyloxy)methyl>pyrrolidine

Downstream raw materials:

(S)-2-Benzyloxymethyl-1-chloromethanesulfonyl-pyrrolidine

O-benzyl-N-<(E)-3-p-tolyl-2-butenyl>-(S)-prolinol

(S)-2-Benzyloxymethyl-1-{2-[2,2-dimethyl-cyclopent-(E)-ylidene]-ethyl}-pyrrolidine

(S)-2-Benzyloxymethyl-1-ethanesulfonyl-pyrrolidine