3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

Base Information

• Chemical Name: 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne
• CAS No.: 89635-79-0
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• DSSTox Substance ID: DTXSID90593315
• Nikkaji Number: J695.227E
• Wikidata: Q82487774
• Mol file: 89635-79-0.mol

Synonyms:89635-79-0;mPEG2-Propyne;1-Propyne, 3-[2-(2-methoxyethoxy)ethoxy]-;3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne;3-(2-(2-Methoxyethoxy)ethoxy)prop-1-yne;1-METHOXY-2-[2-(PROP-2-YN-1-YLOXY)ETHOXY]ETHANE;SCHEMBL8928;DTXSID90593315;LQAWCLHWBNQCHM-UHFFFAOYSA-N;3-[2-(2-Methoxy-ethoxy)-ethoxy]-propyne;CS-0459324;F80848

Chemical Property of 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

Chemical Property:

• Boiling Point: 101-102 °C(Press: 16 Torr)
• PSA: 27.69000
• Density: 0.967±0.06 g/cm3(Predicted)
• LogP: 0.29920
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 158.094294304
• Heavy Atom Count: 11
• Complexity: 114

Purity/Quality:

>98.00% ^*data from raw suppliers

mPEG2-Propyne 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCCOCCOCC#C

Technology Process of 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne

There total 3 articles about 3-[2-(2-Methoxyethoxy)ethoxy]prop-1-yne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-(2-methoxyethoxy)ethyl alcohol (111-77-3,95507-80-5) + propargyl bromide (106-96-7) → O-propargyl-O'-methyl-di(ethylene glycol) (89635-79-0)

Guidance literature:

2-(2-methoxyethoxy)ethyl alcohol; With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

propargyl bromide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 9.0%

2-bromoethyl 2-methoxyethyl ether (54149-17-6,92450-98-1) + propargyl alcohol (107-19-7) → O-propargyl-O'-methyl-di(ethylene glycol) (89635-79-0)

Guidance literature:

propargyl alcohol; With sodium hydride; In tetrahydrofuran; at 5 - 20 ℃;

2-bromoethyl 2-methoxyethyl ether; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

→ O-propargyl-O'-methyl-di(ethylene glycol) (89635-79-0)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.5h; Inert atmosphere;

In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

upstream raw materials:

2-(2-methoxyethoxy)ethyl alcohol

propargyl bromide

2-bromoethyl 2-methoxyethyl ether

propargyl alcohol

Downstream raw materials:

2-((4-Amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chloro benzyl)-5-(3-(2-(2-methoxyethoxy)ethoxy)prop-1-yn-1-yl)quinazolin-4(3H)-one