6-(Phenethylamino)quinoline-5,8-dione

Base Information

Chemical Name:6-(Phenethylamino)quinoline-5,8-dione
CAS No.:35976-63-7
Molecular Formula:C17H14N2O2
Molecular Weight:278.31
Hs Code.:
NSC Number:186021
DSSTox Substance ID:DTXSID40307020
Wikidata:Q82054344

Synonyms:35976-63-7;NSC186021;6-(phenethylamino)quinoline-5,8-dione;DTXSID40307020;5, 6-[(2-phenylethyl)amino]-;NSC-186021;6-(Phenethylamino)-5,8-quinolinequinone

Suppliers and Price of 6-(Phenethylamino)quinoline-5,8-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6-(Phenethylamino)quinoline-5,8-dione

Chemical Property:

Vapor Pressure:9.66E-10mmHg at 25°C
Boiling Point:489.8°C at 760 mmHg
Flash Point:250°C
Density:1.28g/cm³
XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:278.105527694
Heavy Atom Count:21
Complexity:438

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)CCNC2=CC(=O)C3=C(C2=O)C=CC=N3

Technology Process of 6-(Phenethylamino)quinoline-5,8-dione

There total 4 articles about 6-(Phenethylamino)quinoline-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 10470-83-4
5,8-quinolinedione

: 7-(phenethylamino)quinoline-5,8-dione

: 35976-63-7
6-phenethylamino-quinoline-5,8-dione

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethanol; for 5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2013.11.003

Reference yield:

: 4008-48-4
nitroxoline

: 7-(phenethylamino)quinoline-5,8-dione

: 35976-63-7
6-phenethylamino-quinoline-5,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: sodium dithionite / tetrahydrofuran; water / 0.25 h / 55 °C / Inert atmosphere

2: sulfuric acid; sodium dichromate / water; dichloromethane / 1 h / 0 °C

3: N-ethyl-N,N-diisopropylamine / ethanol / 5 h / Inert atmosphere; Reflux

With sodium dithionite; sodium dichromate; sulfuric acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; water; 3: |Michael Addition;
DOI:10.1016/j.bmc.2013.11.003

Reference yield:

: 13207-66-4
5-amino-8-hydroxyquinoline

: 7-(phenethylamino)quinoline-5,8-dione

: 35976-63-7
6-phenethylamino-quinoline-5,8-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; sodium dichromate / water; dichloromethane / 1 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / ethanol / 5 h / Inert atmosphere; Reflux

With sodium dichromate; sulfuric acid; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; water; 2: |Michael Addition;
DOI:10.1016/j.bmc.2013.11.003