N-(3,5-Dichlorophenyl)maleimide

Base Information

• Chemical Name: N-(3,5-Dichlorophenyl)maleimide
• CAS No.: 24096-52-4
• Molecular Formula: C10H5Cl2NO2
• Molecular Weight: 242.061
• Hs Code.: 2925190090
• DSSTox Substance ID: DTXSID10178820
• Nikkaji Number: J732.937G
• Wikidata: Q83049302
• ChEMBL ID: CHEMBL3416535
• Mol file: 24096-52-4.mol

Synonyms:3,5-NDPM;N-(3,5-dichlorophenyl)maleimide

Chemical Property of N-(3,5-Dichlorophenyl)maleimide

Chemical Property:

• Vapor Pressure: 1.74E-06mmHg at 25°C
• Refractive Index: 1.648
• Boiling Point: 396.2 °C at 760 mmHg
• Flash Point: 193.4 °C
• PSA: 37.38000
• Density: 1.57 g/cm³
• LogP: 2.48780
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 240.9697338
• Heavy Atom Count: 15
• Complexity: 301

Purity/Quality:

97% ^*data from raw suppliers

1-(3,5-Dichlorophenyl)-1H-pyrrole-2,5-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=O)N(C1=O)C2=CC(=CC(=C2)Cl)Cl

Technology Process of N-(3,5-Dichlorophenyl)maleimide

There total 7 articles about N-(3,5-Dichlorophenyl)maleimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

maleic anhydride (108-31-6) + 3,5-Dichloroaniline (626-43-7) → 1-(3,5-dichlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (24096-52-4)

Guidance literature:

With acetic acid; for 6h; Reflux;

Reference yield: 60.0%

malic acid (617-48-1,78644-42-5) + 3,5-Dichloroaniline (626-43-7) → 1-(3,5-dichlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (24096-52-4) + D,L-(3,5-Dichlorophenyl)-2-hydroxysuccinimide (119341-82-1)

Guidance literature:

for 0.166667h; Heating; microwave irradiation;

DOI:10.1039/a901520e

Reference yield: 59.8%

(E)-4-((3,5-dichlorophenyl)amino)-4-oxobut-2-enoic acid → 1-(3,5-dichlorophenyl)-2,5-dihydro-1H-pyrrole-2,5-dione (24096-52-4)

Guidance literature:

With sodium acetate; acetic anhydride; at 80 ℃; for 2h;

upstream raw materials:

malic acid

3,5-Dichloroaniline

(Z)-4-((3,5-dichlorophenyl)amino)-4-oxobut-2-enoic acid

maleic anhydride

Downstream raw materials:

N-(3,5-dichlorophenyl)-2-(2,3,4,5-tetrahydro-6-methyl-3-oxopyridazin-4-yl)acetamide