4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole

Base Information

Chemical Name:4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole
CAS No.:89724-06-1
Molecular Formula:C₁₃H₁₁Cl₂NO
Molecular Weight:268.142
Hs Code.:
DSSTox Substance ID:DTXSID40706751

Synonyms:89724-06-1;DTXSID40706751;4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole

Suppliers and Price of 4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:267.0217694
Heavy Atom Count:17
Complexity:272

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(N=C(O1)C=CC2=CC(=CC=C2)Cl)CCl

Technology Process of 4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole

There total 7 articles about 4-(Chloromethyl)-2-[2-(3-chlorophenyl)ethenyl]-5-methyl-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: 89724-05-0
{2-[(E)-2-(3-Chloro-phenyl)-vinyl]-5-methyl-oxazol-4-yl}-methanol

: 89724-06-1
4-Chloromethyl-2-(3-chlorostyryl)-5-methyloxazole

Guidance literature:: With thionyl chloride; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.34.2840

Reference yield: 90.7%

: 89724-06-1
4-Chloromethyl-2-(3-chlorostyryl)-5-methyloxazole

Guidance literature:

Reference yield:

: 39096-24-7,13565-06-5
3-chlorocinnamoyl chloride

: 89724-06-1
4-Chloromethyl-2-(3-chlorostyryl)-5-methyloxazole

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / CHCl₃

2: POCl₃ / 0.5 h / 100 - 110 °C

3: 98.4 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath

4: SOCl₂ / 1 h / Heating

5: NaBH₄, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min

6: 90.7 percent / SOCl₂ / 0.5 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1248/cpb.34.2840