4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-

Base Information

Chemical Name:4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-
CAS No.:89724-11-8
Molecular Formula:C₁₄H₁₂F₃NO₂
Molecular Weight:283.25
Hs Code.:
DSSTox Substance ID:DTXSID50709899

Synonyms:4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-;DTXSID50709899;QGYQPQINMNTARU-UHFFFAOYSA-N;(5-Methyl-2-{2-[3-(trifluoromethyl)phenyl]ethenyl}-1,3-oxazol-4-yl)methanol

Suppliers and Price of 4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:283.08201311
Heavy Atom Count:20
Complexity:346

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(N=C(O1)C=CC2=CC(=CC=C2)C(F)(F)F)CO

Technology Process of 4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]-

There total 6 articles about 4-Oxazolemethanol, 5-methyl-2-[2-[3-(trifluoromethyl)phenyl]ethenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

: 89724-11-8
4-Hydroxymethyl-5-methyl-2-(3-trifluoromethylstyryl)oxazole

Guidance literature:

Reference yield:

: 5-Methyl-2-[(E)-2-(3-trifluoromethyl-phenyl)-vinyl]-oxazole-4-carbonyl chloride

: 89724-11-8
4-Hydroxymethyl-5-methyl-2-(3-trifluoromethylstyryl)oxazole

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; In 1,2-dimethoxyethane; Yield given; ice cooling 30 min, reflux 30 min;
DOI:10.1248/cpb.34.2840

Reference yield:

: 60689-14-7,64379-91-5
trans-3-(trifluoromethyl)cinnamoyl chloride

: 89724-11-8
4-Hydroxymethyl-5-methyl-2-(3-trifluoromethylstyryl)oxazole

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CHCl₃

2: POCl₃ / 0.5 h / 100 - 110 °C

3: 99.4 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath

4: SOCl₂ / 1 h / Heating

5: NaBH₄, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1248/cpb.34.2840