4-Oxazolemethanol, 5-methyl-2-(1-methyl-3-cyclohexen-1-yl)-

Base Information

• Chemical Name: 4-Oxazolemethanol, 5-methyl-2-(1-methyl-3-cyclohexen-1-yl)-
• CAS No.: 89724-37-8
• Molecular Formula: C₁₂H₁₇NO₂
• Molecular Weight: 207.272
• Mol file: 89724-37-8.mol

Synonyms:

Chemical Property of 4-Oxazolemethanol, 5-methyl-2-(1-methyl-3-cyclohexen-1-yl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Oxazolemethanol, 5-methyl-2-(1-methyl-3-cyclohexen-1-yl)-

There total 6 articles about 4-Oxazolemethanol, 5-methyl-2-(1-methyl-3-cyclohexen-1-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.1%

→ 4-Hydroxymethyl-5-methyl-2-(1-methyl-3-cyclohexen-1-yl)oxazole (89724-37-8)

Guidance literature:

Reference yield:

5-Methyl-2-(1-methyl-cyclohex-3-enyl)-oxazole-4-carbonyl chloride → 4-Hydroxymethyl-5-methyl-2-(1-methyl-3-cyclohexen-1-yl)oxazole (89724-37-8)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In 1,2-dimethoxyethane; ice cooling 30 min, reflux 30 min;

DOI:10.1248/cpb.34.2840

Reference yield:

5-Methyl-2-(1-methyl-3-cyclohexen-1-yl)-4-oxazolecarboxylic acid (89724-36-7) → 4-Hydroxymethyl-5-methyl-2-(1-methyl-3-cyclohexen-1-yl)oxazole (89724-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / 1 h / Heating

2: NaBH₄, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min

With hydrogenchloride; sodium tetrahydroborate; thionyl chloride; In 1,2-dimethoxyethane;

DOI:10.1248/cpb.34.2840

upstream raw materials:

5-Methyl-2-(1-methyl-3-cyclohexen-1-yl)-4-oxazolecarboxylic acid

1-methyl-cyclohex-3-enecarbonyl chloride

Downstream raw materials:

[5-Methyl-2-(1-methyl-cyclohex-3-enyl)-oxazol-4-yl]-acetonitrile

5-methyl-2-(1-methyl-3-cyclohexen-1-yl)-4-oxazoleacetic acid

Refernces

• 1、 -. "Oxazoleacetic acid derivatives". . . Retrieved 2008/06/13.