Icilin

Base Information

Chemical Name:Icilin
CAS No.:36945-98-9
Molecular Formula:C16H13 N3 O4
Molecular Weight:311.297
Hs Code.:2933599090
European Community (EC) Number:636-832-1
UNII:CS70PZQ4QJ
DSSTox Substance ID:DTXSID70190442
Nikkaji Number:J22.641F
Wikipedia:Icilin
Wikidata:Q5986473
Pharos Ligand ID:UPLB6QQBRNLF
ChEMBL ID:CHEMBL258405
Mol file:36945-98-9.mol

Synonyms:1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-1,2,3,6-tetrahydropyrimidin-2-one;AG 3-5;AG-3-5 compound;icilin

Suppliers and Price of Icilin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Icilin
10mg
$ 389.00

TRC
Icilin
1g
$ 475.00

Tocris
Icilin ≥98%(HPLC)
10
$ 150.00

Tocris
Icilin ≥98%(HPLC)
50
$ 628.00

DC Chemicals
ICILIN >98%
1 g
$ 1200.00

DC Chemicals
ICILIN >98%
250 mg
$ 600.00

CSNpharm
Icilin
10mg
$ 56.00

CSNpharm
Icilin
25mg
$ 112.00

CSNpharm
Icilin
50mg
$ 205.00

Crysdot
Icilin(AG3-5) 98+%
50mg
$ 231.00

Total 52 raw suppliers

Chemical Property of Icilin

Chemical Property:

Appearance/Colour:Light yellow solid.
Vapor Pressure:9.67E-15mmHg at 25°C
Melting Point:200-208ºC
Boiling Point:594.8 ºC at 760 mmHg
PKA:9.94±0.35(Predicted)
Flash Point:313.5 ºC
PSA：98.39000
Density:1.415 g/cm³
LogP:3.78810
Storage Temp.:Store at RT
Solubility.:DMSO: 15 mg/mL, soluble
XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:311.09060590
Heavy Atom Count:23
Complexity:502

Purity/Quality:

99% ^*data from raw suppliers

Icilin ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 20/21/22
Safety Statements: 26-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C=C(NC(=O)N1C2=CC=CC=C2O)C3=CC(=CC=C3)[N+](=O)[O-]
Description Icilin (36945-98-9) is an activator of cold-sensitive TRP channels with 2.5-fold greater efficacy and 200-fold greater potency than menthol (EC50?= 0.36 μM for CRM1, rat orthologue of TRPM8).1 Activator at TRPM8 (EC50?= 0.2 μM)2?and ANKTM1(TRPA1)3. Activator effects require Ca2+?and are pH dependent.2,4?Icilin induced G1?arrest in PC-3 prostate cancer cells without cell death.5
Uses Icilin has been used as cooling agent in anterior ventromedial preoptic area (VMPO) neurons.

Technology Process of Icilin

There total 1 articles about Icilin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: