Phosphonic acid, [hydroxy(4-methylphenyl)methyl]-

Base Information

• Chemical Name: Phosphonic acid, [hydroxy(4-methylphenyl)methyl]-
• CAS No.: 89758-98-5
• Molecular Formula: C8H11O4P
• Molecular Weight: 202.147
• Mol file: 89758-98-5.mol

Synonyms:

Chemical Property of Phosphonic acid, [hydroxy(4-methylphenyl)methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, [hydroxy(4-methylphenyl)methyl]-

There total 5 articles about Phosphonic acid, [hydroxy(4-methylphenyl)methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dibenzyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate → 1-hydroxy-1-(4-methylphenyl)-methylphosphonic acid (89758-98-5)

Guidance literature:

dibenzyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate; With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 0.15h; under 7500.75 Torr; Autoclave;

for 1h;

DOI:10.1002/hc.21436

Reference yield:

dimethyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate (100134-07-4) → 1-hydroxy-1-(4-methylphenyl)-methylphosphonic acid (89758-98-5) + methyl hydrogen 1-(4-methylphenyl)-1-hydroxymethylphosphonate

Guidance literature:

With hydrogenchloride; In water; for 1.26667h; Kinetics; Reflux;

DOI:10.3390/molecules25173793

Reference yield:

4-methyl-benzaldehyde (104-87-0) → 1-hydroxy-1-(4-methylphenyl)-methylphosphonic acid (89758-98-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum oxide; potassium fluoride / 0.5 h / 20 °C

2: hydrogenchloride; water

With hydrogenchloride; aluminum oxide; potassium fluoride; water;

DOI:10.1080/10426507.2010.511512

upstream raw materials:

dimethyl 1-hydroxy-1-(4-methylphenyl)methylphosphonate

diethyl hydroxy(p-tolyl)methylphosphonate

4-methyl-benzaldehyde

Refernces

• 1、 Harsági, Nikoletta,Rádai, Zita,Szigetvári, áron,Kóti, János,Keglevich, Gy?rgy. "Optimization and a Kinetic Study on the Acidic Hydrolysis of Dialkyl α-Hydroxybenzylphosphonates". . . Retrieved 2020/09/04.
• 2、 Rádai, Zita,Szeles, Petra,Kiss, Nóra Zsuzsa,Heged?s, László,Windt, Tímea,Nagy, Veronika,Keglevich, Gy?rgy. "Green synthesis and cytotoxic activity of dibenzyl α-hydroxyphosphonates and α-hydroxyphosphonic acids". . . Retrieved 2018/09/25.