3-Piperidinecarboxylic acid, 3-methyl-2-oxo-

Base Information

• Chemical Name: 3-Piperidinecarboxylic acid, 3-methyl-2-oxo-
• CAS No.: 89775-75-7
• Molecular Formula: C7H11NO3
• Molecular Weight: 157.169
• Mol file: 89775-75-7.mol

Synonyms:3-Piperidinecarboxylic acid,3-methyl-2-oxo;3-methyl-2-oxo-piperidine-3-carboxylic acid;

Chemical Property of 3-Piperidinecarboxylic acid, 3-methyl-2-oxo-

Chemical Property:

• PSA: 69.89000
• LogP: 0.26320

Purity/Quality:

3-methyl-2-oxopiperidine-3-carboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Piperidinecarboxylic acid, 3-methyl-2-oxo-

There total 3 articles about 3-Piperidinecarboxylic acid, 3-methyl-2-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester (29681-78-5) → 3-methyl-2-oxopiperidine-3-carboxylic acid (89775-75-7)

Guidance literature:

With lithium hydroxide; In methanol; water; at 20 ℃; for 22h; Inert atmosphere;

DOI:10.1021/jacs.7b08496

Reference yield:

diethyl 2-[3-(1,3-dioxoisoindolin-2-yl)propyl]-2-methylpropanedioate (63399-70-2) → 3-methyl-2-oxopiperidine-3-carboxylic acid (89775-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / ethanol / 16 h / 80 °C

2: sodium hydroxide / methanol; water / 3 h / 25 °C

With hydrazine hydrate; sodium hydroxide; In methanol; ethanol; water;

Reference yield:

→ 3-methyl-2-oxopiperidine-3-carboxylic acid (89775-75-7)

Guidance literature:

2-Oxo-3-methyl-piperidin-carbonsaeure-(3)-ethylester, aq. KOH;

upstream raw materials:

3-methyl-2-oxopiperidine-3-carboxylic acid ethyl ester

diethyl 2-[3-(1,3-dioxoisoindolin-2-yl)propyl]-2-methylpropanedioate

Downstream raw materials:

C₃₃H₄₁N₅O₇S

C₄₂H₄₁N₇O₁₁S₂

C₃₂H₃₅N₅O₈S

C₃₂H₃₉N₅O₇S