(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name)

Base Information

Chemical Name:(2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name)
CAS No.:139888-13-4
Molecular Formula:C10H12N4O4
Molecular Weight:252.2267
Hs Code.:
Mol file:139888-13-4.mol

Synonyms:

Suppliers and Price of (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name)

Chemical Property:

Vapor Pressure:2.79E-16mmHg at 25°C
Boiling Point:588.1°Cat760mmHg
Flash Point:309.5°C
Density:1.68g/cm³

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name)

There total 18 articles about (2R,3S,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-3-hydroxy-2-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 149218-10-0
Acetic acid (2R,3S,5R)-2-acetoxymethyl-2-cyano-5-(2-oxo-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 139888-13-4
4'-Cyano-2'-deoxycytidine

Guidance literature:: With ammonium hydroxide;
DOI:10.1016/S0040-4039(00)77667-2

Reference yield: 62.0%

: 232588-82-8
1-<3-O-(tert-butyldimethylsilyl)-5-O-(tert-butyldiphenylsilyl)-4α-cyano-2-deoxy-β-D-ribo-pentofuranosyl>cytosine

: 139888-13-4
4'-Cyano-2'-deoxycytidine

Guidance literature:: With ammonium fluoride; In methanol; Heating;
DOI:10.1021/jm990050i

Reference yield:

: N-{1-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-diphenyl-silanyloxymethyl)-5-cyano-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

: 139888-13-4
4'-Cyano-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo<5.4.0>undec-7-ene, methanol / 0.75 h / Ambient temperature

2: 62 percent / NH₄F / methanol / Heating

With methanol; ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol;
DOI:10.1021/jm990050i