4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE

Base Information

• Chemical Name: 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE
• CAS No.: 90151-10-3
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• Mol file: 90151-10-3.mol

Synonyms:Picolinamide,4-methoxy- (7CI);

Chemical Property of 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE

Chemical Property:

• Vapor Pressure: 0.000513mmHg at 25°C
• Melting Point: 149.3°C
• Refractive Index: 1.55
• Boiling Point: 312.9 °C at 760 mmHg
• Flash Point: 143.1 °C
• PSA: 65.21000
• Density: 1.152g/cm³
• LogP: 0.88940
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

4-Methoxypicolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE

There total 4 articles about 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxypyridine-2-carboxylic acid (29082-91-5) → 4-methoxypyridine-2-carboxamide (90151-10-3)

Guidance literature:

4-methoxypyridine-2-carboxylic acid; With phosphorus pentachloride; In toluene; at 100 ℃; for 4h;

With ammonium hydroxide; In toluene; at 20 ℃; for 1h; Cooling with ice;

Reference yield: 88.0%

4-methoxypyridine (620-08-6,1232006-56-2) + formamide (77287-34-4,77287-35-5,60100-09-6) → 4-methoxypyridine-2-carboxamide (90151-10-3)

Guidance literature:

With dipotassium peroxodisulfate; oxygen; sodium formate; silver nitrate; In water; at 80 ℃; for 4h; regioselective reaction; Schlenk technique;

DOI:10.1055/s-0035-1561975

Reference yield: 85.0%

methyl 4-methoxypicolinate (29681-43-4) → 4-methoxypyridine-2-carboxamide (90151-10-3)

Guidance literature:

With ammonia; In methanol; for 5h; Heating;

DOI:10.1039/b105420c

upstream raw materials:

methyl 4-methoxypicolinate

4-methoxypyridine

formamide

4-methoxypyridine-2-carboxylic acid

Downstream raw materials:

2-amino-4-methoxypyridine

Refernces

• 1、 Han, Wei,Jin, Fengli,Zhao, Qian,Du, Hongyan,Yao, Lifang. "Acid-Free Silver-Catalyzed Cross-Dehydrogenative Carbamoylation of Pyridines with Formamides". supporting information. p. 1854 - 1859. Retrieved 2016/07/16.
• 2、 Meigh,Alvarez,Joule. "Cyclic ureas as ortho directing substituents". . p. 2012 - 2021. Retrieved 2007/10/03.