4,6-dihydroxybenzofuran-3(2H)-one

Base Information

Chemical Name:4,6-dihydroxybenzofuran-3(2H)-one
CAS No.:3260-49-9
Molecular Formula:C8H6O4
Molecular Weight:166.133
Hs Code.:2932999099
NSC Number:19025
DSSTox Substance ID:DTXSID00280906
Nikkaji Number:J1.540.760C
Wikidata:Q72466488
Mol file:3260-49-9.mol

Synonyms:4,6-dihydroxybenzofuran-3(2H)-one;3260-49-9;4,6-dihydroxy-1-benzofuran-3-one;4,6-dihydroxy-1-benzofuran-3(2H)-one;MFCD00597844;4,6-dihydroxybenzofuran-3-one;3(2h)-benzofuranone, 4,6-dihydroxy-;4,6-dihydroxy-3-benzofuranone;NSC19025;4,6-dihydroxy-coumaran-3-one;SCHEMBL1428288;4,6-dihydroxy-benzofuran-3-one;DTXSID00280906;OPSLRXQDYBYKHC-UHFFFAOYSA-N;4,6-dihydroxybenzo[b]furan-3-one;BBL034781;NSC-19025;STK922918;ZB0717;AKOS000266980;SY248379;CS-0060207;VU0421903-2;W18360;F3139-1625

Suppliers and Price of 4,6-dihydroxybenzofuran-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4,6-Dihydroxy-3(2H)-benzofuranone
100mg
$ 355.00

TRC
4,6-Dihydroxy-3(2H)-benzofuranone
250mg
$ 865.00

Crysdot
4,6-Dihydroxybenzofuran-3(2H)-one 97%
5g
$ 1017.00

Crysdot
4,6-Dihydroxybenzofuran-3(2H)-one 97%
1g
$ 490.00

Crysdot
4,6-Dihydroxybenzofuran-3(2H)-one 97%
10g
$ 1439.00

Chemenu
4,6-dihydroxybenzofuran-3(2H)-one 97%
10g
$ 1356.00

Chemenu
4,6-dihydroxybenzofuran-3(2H)-one 97%
1g
$ 463.00

Chemenu
4,6-dihydroxybenzofuran-3(2H)-one 97%
5g
$ 959.00

American Custom Chemicals Corporation
4,6-DIHYDROXY-1-BENZOFURAN-3(2H)-ONE 95.00%
5MG
$ 504.48

AK Scientific
4,6-dihydroxybenzofuran-3-one
250mg
$ 243.20

Total 9 raw suppliers

Chemical Property of 4,6-dihydroxybenzofuran-3(2H)-one

Chemical Property:

Vapor Pressure:5.62E-08mmHg at 25°C
Melting Point:260℃
Boiling Point:429.4°Cat760mmHg
PKA:7.43±0.20(Predicted)
Flash Point:187.4°C
PSA：66.76000
Density:1.614g/cm³
LogP:0.67290
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:166.02660867
Heavy Atom Count:12
Complexity:203

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dihydroxy-3(2H)-benzofuranone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)C2=C(C=C(C=C2O1)O)O
Uses 4,6-Dihydroxy-3(2H)-benzofuranone is an intermediate in synthesizing Diosmetin 3’,7-Diglucuronide-d3 (D485042), a labelled Diosmetin 3’,7-Diglucuronide (D485040), which is a metabolite of Diosmetin (D485000) which is a flavonoid often administered in the treatment of chronic venous insufficiency, hemorrhoids, and related affections.

Technology Process of 4,6-dihydroxybenzofuran-3(2H)-one

There total 2 articles about 4,6-dihydroxybenzofuran-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2524-37-0
ethyl orselinate

: 3260-49-9
4,6-dihydroxybenzofuran-3(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / conc. H₂SO₄ / 0.5 h / Ambient temperature

2: 70 percent / NBS, benzoyl peroxide / CCl₄ / 12 h / 140 °C

3: 80 percent / 0.5 h / 120 - 140 °C / 10 Torr

4: 92 percent / aq. K₂CO₃ / methanol / 2 h / Ambient temperature

With N-Bromosuccinimide; Perbenzoic acid; sulfuric acid; potassium carbonate; In methanol; tetrachloromethane;