1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline

Base Information

Chemical Name:1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline
CAS No.:96733-88-9
Molecular Formula:C₂₈H₃₂N₂O₂
Molecular Weight:428.574
Hs Code.:
DSSTox Substance ID:DTXSID40914339

Synonyms:1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline;96733-88-9;Isoquinoline, 1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-;DTXSID40914339;LS-86003;6-Methoxy-2-phenyl-1-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-1,2,3,4-tetrahydroisoquinoline

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline

Chemical Property:

Vapor Pressure:2.51E-14mmHg at 25°C
Boiling Point:599.4°Cat760mmHg
Flash Point:164.9°C
Density:1.139g/cm³
XLogP3:5.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:428.246378268
Heavy Atom Count:32
Complexity:552

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(N(CC2)C3=CC=CC=C3)C4=CC=C(C=C4)OCCN5CCCC5

Technology Process of 1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline

There total 4 articles about 1,2,3,4-Tetrahydro-6-methoxy-2-phenyl-1-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-4-(2-pyrrolidin-1-yl-ethoxy)-benzamide

: 96733-88-9
6-Methoxy-2-phenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: N-[2-(3-methoxy-phenyl)-ethyl]-N-phenyl-4-(2-pyrrolidin-1-yl-ethoxy)-benzamide; With trichlorophosphate; Heating;

With sodium tetrahydroborate; In methanol;
DOI:10.1016/j.bmcl.2004.03.077

Reference yield:

: 51009-27-9
[2-(3-Methoxy-phenyl)-ethyl]-phenyl-amine

: 96733-88-9
6-Methoxy-2-phenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-propanephosphonic cyclic anhydride; DMAP; Et₃N / CH₂Cl₂

2.1: POCl₃ / Heating

2.2: NaBH₄ / methanol

With dmap; triethylamine; 1-propanephosphonic acid cyclic anhydride; trichlorophosphate; In dichloromethane; 2.1: Bischler-Napieralski cyclization;
DOI:10.1016/j.bmcl.2004.03.077

Reference yield:

: 69731-93-7
4-(2-pyrrolidin-1-yl-ethoxy)-benzoic acid

: 96733-88-9
6-Methoxy-2-phenyl-1-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-1,2,3,4-tetrahydro-isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-propanephosphonic cyclic anhydride; DMAP; Et₃N / CH₂Cl₂

2.1: POCl₃ / Heating

2.2: NaBH₄ / methanol

With dmap; triethylamine; 1-propanephosphonic acid cyclic anhydride; trichlorophosphate; In dichloromethane; 2.1: Bischler-Napieralski cyclization;
DOI:10.1016/j.bmcl.2004.03.077