3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

Base Information

Chemical Name:3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione
CAS No.:89931-90-8
Molecular Formula:C11H7F2NO2
Molecular Weight:223.179
Hs Code.:
DSSTox Substance ID:DTXSID90542803
Wikidata:Q82419571

Synonyms:3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione;89931-90-8;SCHEMBL4194142;DTXSID90542803;GKSVVZUTGFAHCB-UHFFFAOYSA-N

Suppliers and Price of 3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

Chemical Property:

XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:223.04448479
Heavy Atom Count:16
Complexity:367

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)C=C(C1=O)C2=CC(=C(C=C2)F)F

Technology Process of 3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

There total 2 articles about 3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 168267-41-2
(3,4-difluorophenyl)boronic acid

: 65060-93-7
N-methyl bromomaleimide

: 89931-90-8
3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

Guidance literature:: With cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; at 40 ℃; for 1 - 6h;

Reference yield:

: 930-88-1
N-methylmaleimide

cupric chloride: cupric chloride

: 3863-11-4
3,4-difluoroaniline

: 89931-90-8
3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

Guidance literature:: With hydrogenchloride; sodium nitrite; In water; isopropyl alcohol; acetone;

Reference yield: 40.0%

: 89931-90-8
3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione

: 923981-85-5
1-(3,4-difluoro-phenyl)-3-methyl-3-aza-bicyclo[3.1.0]hexane-2,4-dione

Guidance literature:: trimethyloxosulfonium chloride; With sodium hydride; In tetrahydrofuran; at 66 ℃; for 2h;

3-(3,4-difluorophenyl)-1-methyl-1H-pyrrole-2,5-dione; In tetrahydrofuran; at 50 - 65 ℃; for 2 - 6h;