1-phthalazineacetic acid, 3,4-dihydro-4-oxo-, hydrazide

Base Information

• Chemical Name: 1-phthalazineacetic acid, 3,4-dihydro-4-oxo-, hydrazide
• CAS No.: 25947-18-6
• Molecular Formula: C₁₀H₁₀N₄O₂
• Molecular Weight: 218.215
• Hs Code.: 2933990090
• Mol file: 25947-18-6.mol

Synonyms:NSC 61003

Chemical Property of 1-phthalazineacetic acid, 3,4-dihydro-4-oxo-, hydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 100.87000
• Density: 1.53g/cm³
• LogP: 0.54670

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Oxo-3,4-dihydrophthalazin-1-yl)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phthalazineacetic acid, 3,4-dihydro-4-oxo-, hydrazide

There total 5 articles about 1-phthalazineacetic acid, 3,4-dihydro-4-oxo-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

ethyl 2-(3-oxo-1,3-dihydro-1-isobenzofuranyliden)acetate (13141-32-7) → 2-(1,2-dihydro-1-oxophthalazin-4-yl)acetohydrazide (25947-18-6)

Guidance literature:

With hydrazine hydrate; In ethanol; for 15h; Reflux;

DOI:10.1016/j.bmc.2021.116161

Reference yield: 70.0%

1,2-Dihydro-1-oxophthalazin-4-ylacetic acid (25947-11-9) → 2-(1,2-dihydro-1-oxophthalazin-4-yl)acetohydrazide (25947-18-6)

Guidance literature:

With hydrazine hydrate; at 110 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2013.07.067

Reference yield:

phthalic anhydride (85-44-9) → 2-(1,2-dihydro-1-oxophthalazin-4-yl)acetohydrazide (25947-18-6)

Guidance literature:

Multi-step reaction with 4 steps

1: chloroform / 5 h / Reflux

2: hydrazine hydrate / ethanol / 2 h / 20 - 90 °C

3: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

4: hydrazine hydrate / 0.5 h / 110 °C

With hydrazine hydrate; lithium hydroxide; In tetrahydrofuran; methanol; ethanol; chloroform; water;

DOI:10.1016/j.bmcl.2013.07.067

upstream raw materials:

phthalic anhydride

ethyl [(E)-3-oxo-1,3-dihydroisobenzofuran-1-ylidene]acetate

1,2-Dihydro-1-oxophthalazin-4-ylacetic acid

ethyl 2-(3-oxo-1,3-dihydro-1-isobenzofuranyliden)acetate

Refernces

• 1、 Agrawal, Madhavi,Kharkar, Prashant,Moghe, Sonali,Mahajan, Tushar,Deka, Vaishali,Thakkar, Chandni,Nair, Amrutha,Mehta, Chirag,Bose, Julie,Kulkarni-Almeida, Asha,Bhedi, Dilip,Vishwakarma, Ram A.. "Discovery of thiazolyl-phthalazinone acetamides as potent glucose uptake activators via high-throughput screening". . p. 5740 - 5743. Retrieved 2013/10/01.