AKOS BRN-1022

Base Information

• Chemical Name: AKOS BRN-1022
• CAS No.: 900174-62-1
• Molecular Formula: C8H10BClO3
• Molecular Weight: 200.43
• Hs Code.: 2931900090
• Mol file: 900174-62-1.mol

Synonyms:(4-chloro-3-ethoxyphenyl)boronic acid;

Chemical Property of AKOS BRN-1022

Chemical Property:

• PSA: 49.69000
• LogP: 0.41850
• Storage Temp.: Room temperature.

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-3-ethoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-3-ethoxyphenylboronic acid

Technology Process of AKOS BRN-1022

There total 2 articles about AKOS BRN-1022 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-bromo-4-chloro-3-ethoxybenzene (900174-61-0) → 3-ethoxy-4-chlorophenylboronic acid (900174-62-1)

Guidance literature:

1-bromo-4-chloro-3-ethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.666667h;

With Triisopropyl borate; In tetrahydrofuran; hexane; at -78 ℃; for 18h;

With hydrogenchloride; water; In tetrahydrofuran; hexane;

Reference yield:

C14H22BClO3 → 3-ethoxy-4-chlorophenylboronic acid (900174-62-1)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; hexanes;

Reference yield: 73.0%

3-ethoxy-4-chlorophenylboronic acid (900174-62-1) + 4-amino-3-bromo-1-β-D-ribofuranosylpyrazolo<3,4-d>pyrimidine (90914-42-4) → 3-(3-ethoxy-4-chlorophenyl)-4-amino-1-β-D-ribofuranosylpyrazolo[3,4-d]pyrimidine

Guidance literature:

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In water; acetonitrile; Inert atmosphere; Reflux;

DOI:10.1021/acs.jmedchem.1c00135

upstream raw materials:

1-bromo-4-chloro-3-ethoxybenzene

Downstream raw materials:

2-(1-Di-tert-butoxycarbonylaminoisoquinolin-6-ylamino)-2-(4-chloro-3-ethoxyphenyl)acetic acid

Refernces

• 1、 -. "PHENYLGLYCINAMIDE DERIVATIVES USEFUL AS ANTICOAGULANTS". Page/Page column 97-98. . Retrieved 2008/06/13.