6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, 1-methylethyl ester

Base Information

• Chemical Name: 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, 1-methylethyl ester
• CAS No.: 90033-87-7
• Molecular Formula: C19H17NO3
• Molecular Weight: 307.349
• Mol file: 90033-87-7.mol

Synonyms:

Chemical Property of 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, 1-methylethyl ester

There total 4 articles about 6-Quinolinecarboxylic acid, 1,4-dihydro-4-oxo-2-phenyl-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

C20H21NO4 → isopropyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-87-7)

Guidance literature:

In diphenylether; at 250 ℃; for 0.166667h; Reflux;

DOI:10.1016/j.ejmech.2019.111584

Reference yield: 73.0%

→ isopropyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-87-7)

Guidance literature:

In diphenylether; at 250 ℃; for 0.166667h;

Reference yield:

4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylic acid (90033-85-5) → isopropyl 4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylate (90033-87-7)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

upstream raw materials:

4-oxo-2-phenyl-1,4-dihydroquinoline-6-carboxylic acid

isopropyl 4-aminobenzoate

ethyl 3-oxo-3-phenylpropionate

Refernces

• 1、 -. "4(1H)-QUINOLONE DERIVATIVES AND USES THEREOF". Paragraph 0272-0274; 0284. . Retrieved 2020/11/30.
• 2、 -. "4-quinolone derivatives having anti-inflammatory, anti-allergic, antitussive, expectorant and antithrombotic activity". . . Retrieved 2008/06/13.