2,6-DICHLORO-N-BENZYL-4-PYRIMIDINAMINE

Base Information

• Chemical Name: 2,6-DICHLORO-N-BENZYL-4-PYRIMIDINAMINE
• CAS No.: 90042-88-9
• Molecular Formula: C11H9Cl2N3
• Molecular Weight: 254.119
• Mol file: 90042-88-9.mol

Synonyms:4-benzilamino-2,6-tricloropirimidina;4-benzylamino-2,6-dichloropyrimidine;

Chemical Property of 2,6-DICHLORO-N-BENZYL-4-PYRIMIDINAMINE

Chemical Property:

• Boiling Point: 409.9±30.0 °C(Predicted)
• PKA: -0.81±0.10(Predicted)
• PSA: 41.04000
• Density: 1.412±0.06 g/cm3(Predicted)
• LogP: 2.81740

Purity/Quality:

95% ^*data from raw suppliers

2,6-DICHLORO-N-(PHENYLMETHYL)-4-PYRIMIDINAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-DICHLORO-N-BENZYL-4-PYRIMIDINAMINE

There total 4 articles about 2,6-DICHLORO-N-BENZYL-4-PYRIMIDINAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester (270929-33-4) → 4-benzilamino-2,6-tricloropirimidina (90042-88-9)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1016/S0040-4020(02)00084-4

Reference yield: 45.0%

→ 4-benzilamino-2,6-tricloropirimidina (90042-88-9)

Guidance literature:

Reference yield:

N-tert-butoxycarbonylbenzylamine (42116-44-9) → 4-benzilamino-2,6-tricloropirimidina (90042-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 20 °C

2: 87 percent / TFA / CH₂Cl₂ / 3 h / 20 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(02)00084-4

upstream raw materials:

2,4,6-trichloropyrimidine

benzylamine

benzyl-(2,6-dichloro-pyrimidin-4-yl)-carbamic acid tert-butyl ester

N-tert-butoxycarbonylbenzylamine

Downstream raw materials:

C₃₈H₅₃ClN₆O₄

N-benzylpyrimidin-4-amine

Refernces

• 1、 Montebugnoli, Dario,Bravo, Pierfrancesco,Corradi, Eleonora,Dettori, Giovanna,Mioskowski, Charles,Volonterio, Alessandro,Wagner, Alain,Zanda, Matteo. "Regioselective 4-amino-de-chlorination of trichloro- and dichloro-pyrimidines with N-sodium carbamates". . p. 2147 - 2153. Retrieved 2007/10/03.