Chemical Property of Securinine
Chemical Property:
- Vapor Pressure:1.32E-08mmHg at 25°C
- Melting Point:140-1420C
- Refractive Index:1.5300 (estimate)
- Boiling Point:459 ºC at 760 mmHg
- PKA:8.29±0.20(Predicted)
- Flash Point:197 ºC
- PSA：29.54000
- Density:1.3 g/cm3
- LogP:1.34290
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO: ≥25mg/mL
- XLogP3:1.1
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:0
- Exact Mass:217.110278721
- Heavy Atom Count:16
- Complexity:426
- Purity/Quality:
-
98% *data from raw suppliers
Securinine ≥98% (HPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T,Xn
- Statements:
23/24/25-22
- Safety Statements:
36/37/39-45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1CCN2C(C1)C34CC2C=CC3=CC(=O)O4
- Isomeric SMILES:C1CCN2[C@H](C1)[C@]34C[C@H]2C=CC3=CC(=O)O4
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Description
A constituent of the leaves of Securinega suffructicosa Rehd., the base also occurs in Phyllanthus disco ides. It is obtained as yellow crystals and is strongly laevorotatory having [α]20D - 1106°(CHC13), [α]30D - 1106°(CHC13) and[α]20D - 1042° (c 1.0, EtOH). The alkaloid yields a crystalline methiodide, m.p. 235-6°C.
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Uses
Extracted from leaves and roots of Securinega suffruticosa Rehder. The most widely studied of these alkaloids, Securinine, is a specific GABA receptor antagonist and has been found to have significant in vivo CNS activity. GABAA receptor blocker, CNS stimulant
