Oligomycin A, 28-oxo-

Base Information

• Chemical Name: Oligomycin A, 28-oxo-
• CAS No.: 11050-94-5
• Molecular Formula: C45H72 O12
• Molecular Weight: 805.05
• Hs Code.: 29419090
• European Community (EC) Number: 234-275-5
• Metabolomics Workbench ID: 70478
• Nikkaji Number: J39.563C
• Wikidata: Q27107576
• Mol file: 11050-94-5.mol

Synonyms:oligomycin B

Chemical Property of Oligomycin A, 28-oxo-

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 160-161℃
• Boiling Point: 911.4°Cat760mmHg
• PKA: 12.52±0.70(Predicted)
• Flash Point: 260.3°C
• PSA: 197.12000
• Density: 1.17g/cm³
• LogP: 5.06160
• Storage Temp.: −20°C
• Solubility.: ≤30mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
• XLogP3: 6.1
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 12
• Rotatable Bond Count: 3
• Exact Mass: 804.50237773
• Heavy Atom Count: 57
• Complexity: 1470

Purity/Quality:

98%,99%, ^*data from raw suppliers

Oligomycin B ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn,T
• Statements: 20/21/22-68/20/21/22-22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
• Isomeric SMILES: CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)C(=O)C[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
• Description: Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin B is a nonselective inhibitor of the mitochondrial F1FO ATP synthase. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.
• Uses: Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin B is an antibiotic that acts as a nonselective inhibitor of ATP synthase.