N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide

Base Information

Chemical Name:N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide
CAS No.:90141-26-7
Molecular Formula:C₂₁H₂₂N₂O₄S
Molecular Weight:398.483
Hs Code.:
DSSTox Substance ID:DTXSID90530740
Wikidata:Q82402068

Synonyms:90141-26-7;SCHEMBL16639802;DTXSID90530740;AKOS017127076;N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide

Suppliers and Price of N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:398.13002836
Heavy Atom Count:28
Complexity:633

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)CNC(=O)C3=CC4=CC=CC=C4O3

Technology Process of N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide

There total 4 articles about N-{[4-(Piperidine-1-sulfonyl)phenyl]methyl}-1-benzofuran-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.6%

: 110-89-4
piperidine

: 90141-23-4
4-{[(Benzofuran-2-carbonyl)-amino]-methyl}-benzenesulfonyl chloride

: 90141-26-7
Benzofuran-2-carboxylic acid 4-(piperidine-1-sulfonyl)-benzylamide

Guidance literature:: With sodium hydroxide; for 2h; Ambient temperature;
DOI:10.1007/BF00765082

Reference yield:

: 41717-28-6
2-benzofuroyl chloride

: 90141-26-7
Benzofuran-2-carboxylic acid 4-(piperidine-1-sulfonyl)-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60.5 percent / benzene / 5 h

2: 98.1 percent / chlorosulfuric acid / 2 h / -5 - -1 °C

3: 50.6 percent / 10percent aq. NaOH / 2 h / Ambient temperature

With sodium hydroxide; chlorosulphuric acid; In benzene;
DOI:10.1007/BF00765082

Reference yield:

: 100-46-9
benzylamine

: 90141-26-7
Benzofuran-2-carboxylic acid 4-(piperidine-1-sulfonyl)-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60.5 percent / benzene / 5 h

2: 98.1 percent / chlorosulfuric acid / 2 h / -5 - -1 °C

3: 50.6 percent / 10percent aq. NaOH / 2 h / Ambient temperature

With sodium hydroxide; chlorosulphuric acid; In benzene;
DOI:10.1007/BF00765082