1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one

Base Information

Chemical Name:1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one
CAS No.:90176-76-4
Molecular Formula:C₁₇H₁₄ClF₃O
Molecular Weight:326.746
Hs Code.:
DSSTox Substance ID:DTXSID50530988

Synonyms:90176-76-4;1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one;DTXSID50530988

Suppliers and Price of 1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one

Chemical Property:

XLogP3:5.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:326.0685272
Heavy Atom Count:22
Complexity:375

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C(C(=O)CC2=CC(=CC=C2)C(F)(F)F)Cl

Technology Process of 1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one

There total 5 articles about 1-Chloro-1-(4-methylphenyl)-3-[3-(trifluoromethyl)phenyl]propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14062-19-2
p-tolylacetic acid ethyl ester

: 90176-76-4
1-Chloro-1-p-tolyl-3-(3-trifluoromethyl-phenyl)-propan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Claisen condesation

2: 1.) hydrolysis, 2.) decaboxylation

3: 1.) Et₃N, Me₃SiCl, 2.) Cl₂ / 2.) CCl₄

With chloro-trimethyl-silane; chlorine; triethylamine;
DOI:10.1016/S0040-4039(00)99922-2

Reference yield:

: 344874-67-5
3-Oxo-4-p-tolyl-2-(3-trifluoromethyl-phenyl)-butyronitrile

: 90176-76-4
1-Chloro-1-p-tolyl-3-(3-trifluoromethyl-phenyl)-propan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) hydrolysis, 2.) decaboxylation

2: 1.) Et₃N, Me₃SiCl, 2.) Cl₂ / 2.) CCl₄

With chloro-trimethyl-silane; chlorine; triethylamine;
DOI:10.1016/S0040-4039(00)99922-2

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 90176-76-4
1-Chloro-1-p-tolyl-3-(3-trifluoromethyl-phenyl)-propan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: Claisen condesation

2: 1.) hydrolysis, 2.) decaboxylation

3: 1.) Et₃N, Me₃SiCl, 2.) Cl₂ / 2.) CCl₄

With chloro-trimethyl-silane; chlorine; triethylamine;
DOI:10.1016/S0040-4039(00)99922-2