2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile

Base Information

Chemical Name:2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile
CAS No.:90178-63-5
Molecular Formula:C22H13N3O
Molecular Weight:335.365
Hs Code.:
DSSTox Substance ID:DTXSID00531102
Wikidata:Q82402700

Synonyms:90178-63-5;2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile;DTXSID00531102

Suppliers and Price of 2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:335.105862047
Heavy Atom Count:26
Complexity:571

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C#N)OC2=CC=C(C=C2)C3=CC4=C(N3)C=CC(=C4)C#N

Technology Process of 2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile

There total 12 articles about 2-[4-(4-Cyanophenoxy)phenyl]-1H-indole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1162684-30-1
4-amino-3-((4-(4-cyanophenoxy)phenyl)ethynyl)benzonitrile

: 90178-63-5
2-<4-(4-Cyanphenoxy)phenyl>indol-5-carbonitril

Guidance literature:: With (triphenylphosphine)gold(I) chloride; silver perchlorate; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere; Darkness;
DOI:10.3987/COM-08-S(D)8

Reference yield:

: 767-00-0
4-cyanophenol

: 90178-63-5
2-<4-(4-Cyanphenoxy)phenyl>indol-5-carbonitril

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃ / dimethylformamide / 3 h / 155 - 160 °C

2: 12 percent / piperidine / 24 h / 100 °C

3: 77 percent / triethylphosphite / 20 h / Heating

With piperidine; potassium carbonate; triethyl phosphite; In N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 90178-63-5
2-<4-(4-Cyanphenoxy)phenyl>indol-5-carbonitril

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / K₂CO₃ / dimethylformamide / 3 h / 155 - 160 °C

2: 12 percent / piperidine / 24 h / 100 °C

3: 77 percent / triethylphosphite / 20 h / Heating

With piperidine; potassium carbonate; triethyl phosphite; In N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302