2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile

Base Information

Chemical Name:2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile
CAS No.:90178-66-8
Molecular Formula:C₂₂H₁₃N₃O
Molecular Weight:335.365
Hs Code.:
DSSTox Substance ID:DTXSID60531103
Wikidata:Q82402701

Synonyms:90178-66-8;2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile;DTXSID60531103

Suppliers and Price of 2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
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Total 0 raw suppliers

Chemical Property of 2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile

Chemical Property:

XLogP3:4.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:335.105862047
Heavy Atom Count:26
Complexity:579

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)OC2=CC=C(C=C2)C#N)C3=CC4=C(N3)C=C(C=C4)C#N

Technology Process of 2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile

There total 5 articles about 2-[3-(4-Cyanophenoxy)phenyl]-1H-indole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 90178-70-4
4-Cyan-3'-(4-cyanphenoxy)-2-nitrostilben

: 90178-66-8
2-<3-(4-Cyanphenoxy)phenyl>indol-6-carbonitril

Guidance literature:: With triethyl phosphite; for 20h; Heating;
DOI:10.1002/jlac.198419840302

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 90178-66-8
2-<3-(4-Cyanphenoxy)phenyl>indol-6-carbonitril

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / K₂CO₃ / dimethylformamide / 3 h / 155 - 160 °C

2: 54 percent / piperidine / 24 h / 100 °C

3: 53 percent / triethylphosphite / 20 h / Heating

With piperidine; potassium carbonate; triethyl phosphite; In N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 90178-66-8
2-<3-(4-Cyanphenoxy)phenyl>indol-6-carbonitril

Guidance literature:: Multi-step reaction with 3 steps

1: 35 percent / K₂CO₃ / dimethylformamide / 3 h / 155 - 160 °C

2: 54 percent / piperidine / 24 h / 100 °C

3: 53 percent / triethylphosphite / 20 h / Heating

With piperidine; potassium carbonate; triethyl phosphite; In N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302