4-(4-(Hydroxymethyl)phenoxy)benzonitrile

Base Information

Chemical Name:4-(4-(Hydroxymethyl)phenoxy)benzonitrile
CAS No.:90178-73-7
Molecular Formula:C14H11NO2
Molecular Weight:225.247
Hs Code.:
DSSTox Substance ID:DTXSID10531092
Wikidata:Q82402681

Synonyms:4-(4-(hydroxymethyl)phenoxy)benzonitrile;4-[4-(Hydroxymethyl)phenoxy]benzonitrile;90178-73-7;SCHEMBL3233441;DTXSID10531092;AKOS005880913;EN300-12789815

Suppliers and Price of 4-(4-(Hydroxymethyl)phenoxy)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(Hydroxymethyl)phenoxy)benzonitrile

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:225.078978594
Heavy Atom Count:17
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CO)OC2=CC=C(C=C2)C#N

Technology Process of 4-(4-(Hydroxymethyl)phenoxy)benzonitrile

There total 8 articles about 4-(4-(Hydroxymethyl)phenoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.8%

: 90178-71-5
4-(4-formylphenoxy)benzonitrile

: 90178-73-7
4-(4-(hydroxymethyl)phenoxy)benzonitrile

Guidance literature:: 4-(4-formylphenoxy)benzonitrile; With sodium tetrahydroborate; In methanol; at 20 ℃; for 0.5h;

With water; In methanol;

Reference yield: 97.8%

: 90178-73-7
4-(4-(hydroxymethyl)phenoxy)benzonitrile

Guidance literature:

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 90178-73-7
4-(4-(hydroxymethyl)phenoxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / dimethylformamide / 3 h / 155 - 160 °C

2: 89 percent / sodium tetrahydroborate / H₂O; methanol / 0.5 h

With sodium tetrahydroborate; potassium carbonate; In methanol; water; N,N-dimethyl-formamide;
DOI:10.1002/jlac.198419840302