Carbamic acid, [1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)-

Base Information

Chemical Name:Carbamic acid, [1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)-
CAS No.:90181-31-0
Molecular Formula:C₂₃H₃₈N₆O₅Si
Molecular Weight:506.677
Hs Code.:

Carbamic acid,
[1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth
oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)-

Synonyms:

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Chemical Property of Carbamic acid, [1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)-

There total 4 articles about Carbamic acid, [1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2-oxo-2-[[2-[(phenylmeth oxy)methyl]-2H-tetrazol-5-yl]amino]ethyl]-, 1,1-dimethylethyl ester, (S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 3587-60-8
Benzyloxymethyl chloride

: 90181-27-4
[(S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(1H-tetrazol-5-ylcarbamoyl)-ethyl]-carbamic acid tert-butyl ester

: 90181-31-0
[(S)-1-(2-Benzyloxymethyl-2H-tetrazol-5-ylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester

: 90181-29-6
[(S)-1-(1-Benzyloxymethyl-1H-tetrazol-5-ylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In acetonitrile;
DOI:10.1016/S0040-4039(01)80060-5

Reference yield:

: 3262-72-4
(S)-N-(tert-butoxycarbonyl)serine

: 90181-31-0
[(S)-1-(2-Benzyloxymethyl-2H-tetrazol-5-ylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / CH₃CO₂H / methanol; H₂O

2: 1.) iBuOCOCl N-methylmorpholine, 2.) N-methylmorpholine / 1.) THF, 1 h, - 15 deg C,

3: 32 percent / Et₃N / acetonitrile

With 4-methyl-morpholine; acetic acid; triethylamine; isobutyl chloroformate; In methanol; water; acetonitrile;
DOI:10.1016/S0040-4039(01)80060-5

Reference yield:

: 123254-10-4,90181-25-2
(2S)-2-tert-butoxycarbonylamino-3-(tert-butyldimethylsilanyloxy)propionic acid

: 90181-31-0
[(S)-1-(2-Benzyloxymethyl-2H-tetrazol-5-ylcarbamoyl)-2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) iBuOCOCl N-methylmorpholine, 2.) N-methylmorpholine / 1.) THF, 1 h, - 15 deg C,

2: 32 percent / Et₃N / acetonitrile

With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In acetonitrile;
DOI:10.1016/S0040-4039(01)80060-5