Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-

Base Information

Chemical Name:Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-
CAS No.:90210-23-4
Molecular Formula:C14H20N2O2
Molecular Weight:248.325
Hs Code.:
DSSTox Substance ID:DTXSID10406291
Wikidata:Q82211199

Synonyms:90210-23-4;(4-hydroxyphenyl)(4-isopropylpiperazin-1-yl)methanone;Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-;(4-hydroxyphenyl)-(4-propan-2-ylpiperazin-1-yl)methanone;SCHEMBL4919917;DTXSID10406291;ILKHFVMVAPOCMU-UHFFFAOYSA-N;MFCD06741433;AKOS003586409;WS-01889;1-(4-hydroxybenzoyl)-4-isopropylpiperazine;W13407;4-[4-(propan-2-yl)piperazine-1-carbonyl]phenol

Suppliers and Price of Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-

Chemical Property:

PSA：43.78000
LogP:1.43420
XLogP3:0.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:248.152477885
Heavy Atom Count:18
Complexity:278

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N1CCN(CC1)C(=O)C2=CC=C(C=C2)O

Technology Process of Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)-

There total 6 articles about Piperazine, 1-(4-hydroxybenzoyl)-4-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: Acetic acid 4-(4-isopropyl-piperazine-1-carbonyl)-phenyl ester; hydrochloride

: 90210-23-4
(4-hydroxy-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone

Guidance literature:: With potassium carbonate; In methanol; for 1h;
DOI:10.1016/0223-5234(96)85875-2

Reference yield:

: 4318-42-7
1-(1-methylethyl)piperazine

: 90210-23-4
(4-hydroxy-phenyl)-(4-isopropyl-piperazin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Et₃N, oxalyl chloride / 1) CH₂Cl₂, rt, 1 h; 2) CH₂Cl₂, -10 to 0 deg C, 1 h

2: K₂CO₃ / methanol / 1 h

With oxalyl dichloride; potassium carbonate; triethylamine; In methanol;
DOI:10.1016/S0223-5234(97)89852-2